Abstract
The World Health Organization recommends adding bedaquiline or delamanid to multidrug-resistant tuberculosis (MDR-TB) regimens for which four effective drugs are not available, and delamanid for patients at high risk of poor outcome. To identify patients at risk of unfavourable outcomes who may benefit from the new drugs. Retrospective cohort study of treatment outcomes involving four to five effective drugs for 15-24 months in programmes in Uzbekistan, Georgia, Armenia, Swaziland and Kenya between 2001 and 2011. Of 1433 patients, 48.5% had body mass index (BMI) <18.5 kg/m(2), 72.9% had a high bacillary load, 16.7% were resistant to two injectables, 2.9% were resistant to ofloxacin (OFX) and 3.0% had extensively drug-resistant TB (XDR-TB). Treatment success ranged from 59.7% (no second-line resistance) to 27.0% (XDR-TB). XDR-TB (aOR 8.16, 95%CI 3.22-20.64), resistance to two injectables (aOR 1.90, 95%CI 1.00-3.62) or OFX (aOR 5.56, 95%CI 2.15-14.37), past incarceration (aOR 1.88, 95%CI 1.11-3.2), history of second-line treatment (aOR 3.24, 95%CI 1.53-6.85), low BMI (aOR 2.22, 95%CI 1.56-3.12) and high bacillary load (aOR 2.32, 95%CI 1.15-4.67) were associated with unfavourable outcomes. Patients started on capreomycin rather th...Continue Reading
Citations
Dec 7, 2016·International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases·Mike Frick
Feb 9, 2017·International Journal of Molecular Sciences·Giovanni Battista MiglioriSusanna Esposito
Jun 1, 2017·Expert Review of Respiratory Medicine·Ignacio MonederoAdrián Sánchez-Montalvá
Aug 30, 2017·Respirology : Official Journal of the Asian Pacific Society of Respirology·Keertan DhedaChristoph Lange
Aug 31, 2018·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Ying ZhaoSean Wasserman
Feb 10, 2017·The European Respiratory Journal·Lorenzo GuglielmettiUNKNOWN French MDR-TB Management Group
Jun 25, 2016·The European Respiratory Journal·Marina TadoliniGiovanni Battista Migliori
Mar 24, 2017·The European Respiratory Journal·Emanuele PontaliGiovanni Battista Migliori
May 23, 2017·The European Respiratory Journal·Lorenzo Guglielmetti
Sep 14, 2019·Microbial Drug Resistance : MDR : Mechanisms, Epidemiology, and Disease·Majid Faridgohar
Mar 4, 2020·BMJ : British Medical Journal·Anthony LeeRay Y Chen
Jul 24, 2020·Future Microbiology·Lorenzo GuglielmettiJérôme Robert
Sep 22, 2018·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Lorenzo GuglielmettiUNKNOWN French National Reference Center of Mycobacteria
May 4, 2017·ELife·Madhukar Pai, Jennifer Furin
Aug 2, 2017·Emerging Infectious Diseases·Jay AcharPhilipp du Cros
Jul 4, 2018·American Journal of Respiratory and Critical Care Medicine·Mathieu BastardCatherine Hewison
Apr 20, 2019·Emerging Infectious Diseases·Lawrence MbuagbawChristian Lienhardt
Aug 3, 2017·Emerging Infectious Diseases·Cathy HewisonFrancis Varaine
Apr 6, 2019·Open Forum Infectious Diseases·Eun Hye LeeYoung Ae Kang
Dec 30, 2020·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Ilse TackPetros Isaakidis