Identification of patients with pancreatic adenocarcinoma due to inheritable mutation: Challenges of daily clinical practice

World Journal of Gastrointestinal Oncology
Alexander Jp FultonJuan W Valle

Abstract

Identification of germ-line mutations in pancreatic ductal adenocarcinoma (PDAC) could impact on patient/family. To assess the referral pathways for genetic consultations in PDAC. Electronic records of PDAC patients were reviewed retrospectively. Patients eligible for genetic consultation referral were identified following the European Registry of Hereditary Pancreatitis and Familial Pancreatic Cancer (EUROPAC) criteria. Four-hundred patients were eligible. Of 113 patients (28.3%) meeting EUROPAC criteria, 8.8% were referred for genetic opinion. Germ-line mutations were identified in 0.75% of the whole population. Earlier referrals and increased awareness may be able to overcome the low rate of successful genetic appointments.

References

May 27, 2004·JAMA : the Journal of the American Medical Association·Jay F PiccirilloEdward L Spitznagel
Feb 16, 2007·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Fergus J CouchRalph H Hruban
Jun 26, 2009·The New England Journal of Medicine·Peter C FongJohann S de Bono
Sep 23, 2010·Cancer Research·Marc Tischkowitz, Bing Xia
Dec 14, 2011·Molecular Carcinogenesis·Alison P Klein
Aug 17, 2012·Annals of Surgery·Katherine E PorukSean J Mulvihill
Mar 6, 2013·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Susan M DomchekMark E Robson
Nov 15, 2013·Annals of Oncology : Official Journal of the European Society for Medical Oncology·J-M LeeE C Kohn
Jan 8, 2014·Genes & Development·Anil K Rustgi
Aug 30, 2014·World Journal of Gastroenterology : WJG·Andrew E BeckerAimee L Lucas
Nov 5, 2014·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Bella KaufmanSusan M Domchek
Dec 17, 2014·International Journal of Epidemiology·Patrick Maisonneuve, Albert B Lowenfels
Feb 6, 2015·CA: a Cancer Journal for Clinicians·Lindsey A TorreAhmedin Jemal
Apr 29, 2015·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Elena M Stoffel
May 6, 2015·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Spring HolterSteven Gallinger
Sep 1, 2015·Annals of Oncology : Official Journal of the European Society for Medical Oncology·M DucreuxUNKNOWN ESMO Guidelines Committee
Sep 2, 2015·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Mark E RobsonNoralane M Lindor
Sep 14, 2015·Surgical Oncology Clinics of North America·Ashton A Connor, Steven Gallinger
Oct 7, 2015·Cancer·Erin E Salo-MullenZsofia K Stadler
Dec 15, 2015·Cancer Discovery·Nicholas J RobertsAlison P Klein
Jan 19, 2016·Pancreatology : Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]·Dóra IllésLászló Czakó
Oct 9, 2016·The New England Journal of Medicine·Mansoor R MirzaUNKNOWN ENGOT-OV16/NOVA Investigators
Jan 4, 2017·Journal of the National Comprehensive Cancer Network : JNCCN·Mary B DalySusan Darlow
Mar 31, 2017·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Chen YuanBrian M Wolpin
May 16, 2017·Annual Review of Genomics and Human Genetics·Payal D Shah, Katherine L Nathanson
Aug 3, 2017·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Koji ShindoMichael Goggins
Oct 27, 2017·Oncotarget·Rille PihlakMairéad G McNamara
Dec 11, 2017·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Maeve A LoweryEileen M O'Reilly
Jun 21, 2018·JAMA : the Journal of the American Medical Association·Chunling HuFergus J Couch

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