PMID: 9419444Jan 7, 1998Paper

Identification of peptides for immunotherapy of cancer. It is worth the effort

Critical Reviews in Immunology
M P VeldersW M Kast

Abstract

As the nature of the T cell immune response is defined by T cell receptor recognition of small protein fragments, referred to as peptides, the identification of peptides would lead us to understanding and directing the T-cell-mediated immune response. Immunogenic peptides might be used for vaccination and activation of the immune reaction against cancer- and virus-infected cells. Additionally, the knowledge of immunogenic peptides was expected to lead to blocking of allergic reactions and autoimmune diseases. Based on these assumptions, the search for immunogenic peptides was started in mice and man in the mid-1980s. After a decade of peptide identification and testing in vitro and in vivo, this may be a proper time to evaluate the results from the peptide-related work and determine the possible applications of this knowledge for the next decade. In this review we discuss the identification of peptides, their use in murine models, as well as clinical data from peptide vaccinations or therapies. Potential hazards and limitations of peptide use in immunotherapy and other possible applications for peptides or peptide motifs in immunotherapy are evaluated.

Citations

May 21, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Aaron J JohnsonLarry R Pease
Feb 13, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·R Lo-ManC Leclerc
Apr 19, 2003·Cancer Immunology, Immunotherapy : CII·Michael G E O'RourkeChristopher W Schmidt
Feb 14, 2006·Acta Biochimica Et Biophysica Sinica·Hai-Liang GeYong Zhang
Nov 8, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Lisa A E HarmalaChristopher A Pennell
Dec 5, 2008·Expert Review of Vaccines·Shreya Kanodia, W Martin Kast
Oct 19, 2001·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·A J JohnsonL R Pease
Feb 13, 2001·Journal of Cellular Physiology·D M Da SilvaW M Kast
Dec 6, 2001·Experimental and Molecular Pathology·S J GhimA B Jenson

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