Identification of pharmacophore in bioactive metal complexes: Synthesis, spectroscopic characterization and application

European Journal of Medicinal Chemistry
Ripul MehrotraArchana Dubey

Abstract

Bacteria are amongst the most adaptable organisms on the Earth. The year 2010 was always remarkable for the article published in Lancet Infection Disease by Kumarasamy et al. and the enzyme NDM-1 which makes bacteria resist designed to kill them. Four rhodium(III) chloride complexes with Gatifloxacin have been prepared and characterized by elemental analyses, molar conductance measurements, FTIR, FAB-MS, TGA, (1)H NMR and electronic spectral studies. The general formula for complexes are [X](+)fac-[RhCl(3)(L)(GT)](-); where L = H(2)O, Dimethylsulfoxide (DMSO), Tetramethylenesulfoxide (TMSO); GT = Gatifloxacin and X = Na or [H(DMSO)(2)]. All complexes are found to possess prominent antibacterial activity against pathogenic Escherichia coli and Mycobacterium tuberculosis in comparison to Gatifloxacin.

References

Dec 1, 1994·Antimicrobial Agents and Chemotherapy·S LecomteN J Moreau
Apr 5, 2000·The Journal of Antimicrobial Chemotherapy·J Fung-TomcD Bonner
Aug 23, 2002·Journal of Internal Medicine·B Henriques Normark, S Normark
Dec 17, 2008·Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy·N Padma PriyaC Jayabalakrishnan

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Citations

Sep 14, 2013·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Valentina Uivarosi
Jul 20, 2018·Advanced Pharmaceutical Bulletin·Aura RusuSilvia Imre

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