Identification of phenolic compounds in red wine extract samples and zebrafish embryos by HPLC-ESI-LTQ-Orbitrap-MS

Food Chemistry
Anna Vallverdú-QueraltRosa M Lamuela-Raventós

Abstract

The zebrafish embryo is a highly interesting biological model with applications in different scientific fields, such as biomedicine, pharmacology and toxicology. In this study, we used liquid chromatography/electrospray ionisation-linear ion trap quadrupole-Orbitrap-mass spectrometry (HPLC/ESI-LTQ-Orbitrap-MS) to identify the polyphenol compounds in a red wine extract and zebrafish embryos. Phenolic compounds and anthocyanin metabolites were determined in zebrafish embryos previously exposed to the red wine extract. Compounds were identified by injection in a high-resolution system (LTQ-Orbitrap) using accurate mass measurements in MS, MS(2) and MS(3) modes. To our knowledge, this research constitutes the first comprehensive identification of phenolic compounds in zebrafish by HPLC coupled to high-resolution mass spectrometry.

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Citations

Dec 4, 2015·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Dixin ZouRuichao Lin
Dec 6, 2017·Oxidative Medicine and Cellular Longevity·A Tressera-RimbauA Vallverdú-Queralt
Oct 23, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Vania SaézAnna Vallverdú-Queralt
Apr 9, 2019·Journal of Food Science and Technology·Alexandre GiacobboRosângela Assis Jacques
Mar 3, 2020·Frontiers in Physiology·Sandra Carrera-JuliáEraci Drehmer
Aug 12, 2016·Nutrition and Metabolic Insights·Melissa M MarkoskiAline Marcadenti
May 7, 2019·Central Nervous System Agents in Medicinal Chemistry·Nayana Keyla Seabra de OliveiraLorane Izabel da Silva Hage-Melim
Jun 8, 2018·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Ya-Chu FanChang-Yun Wang
Mar 18, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Danilo Escobar-AvelloAnna Vallverdú-Queralt
Jun 3, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Fang ShengZhengrong Luo

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