Identification of Plasmodiophora brassicae effectors - A challenging goal

Virulence
Edel Pérez-LópezChristopher D Todd

Abstract

Clubroot is an economically important disease affecting Brassica plants worldwide. Plasmodiophora brassicae is the protist pathogen associated with the disease, and its soil-borne obligate parasitic nature has impeded studies related to its biology and the mechanisms involved in its infection of the plant host. The identification of effector proteins is key to understanding how the pathogen manipulates the plant's immune response and the genes involved in resistance. After more than 140 years studying clubroot and P. brassicae, very little is known about the effectors playing key roles in the infection process and subsequent disease progression. Here we analyze the information available for identified effectors and suggest several features of effector genes that can be used in the search for others. Based on the information presented in this review, we propose a comprehensive bioinformatics pipeline for effector identification and provide a list of the bioinformatics tools available for such.

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Citations

Jan 12, 2020·The Journal of Eukaryotic Microbiology·Edel Pérez-LópezPeta C Bonham-Smith
Mar 7, 2021·Pathogens·Arne Schwelm, Jutta Ludwig-Müller
Mar 3, 2021·Genome Génome / Conseil National De Recherches Canada·Jakir HasanHabibur Rahman
Jun 15, 2021·Frontiers in Microbiology·Melaine González-García, Edel Pérez-López
Jul 27, 2021·Frontiers in Microbiology·Kévin GazengelStéphanie Daval
Nov 23, 2021·Frontiers in Microbiology·Leonardo Galindo-GonzálezStephen E Strelkov
Aug 24, 2020·Microbiological Research·Ayesha AhmedYueqiu He

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Datasets Mentioned

BETA
AFK13134
AM411657

Methods Mentioned

BETA
RNA-seq

Software Mentioned

WoLF PSORT
TargetP Tool
SignalP
TargetP
Trimmomatic

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