Identification of platelet-derived growth factor D in human chronic allograft nephropathy

Human Pathology
Gang LiuC E Alpers

Abstract

Chronic allograft nephropathy (CAN), a descriptive term denoting chronic scarring injury of the renal parenchyma and vasculature in allograft kidneys arising from various etiologies including chronic rejection, is the most common cause of late allograft failure, but mediators of this progressive injury largely remain unknown. We hypothesized that platelet-derived growth factor D (PDGF-D) and its specific receptor PDGF-Rbeta may be an important mediator in the pathogenesis of CAN and, hence, sought to identify its expression in this setting. Allograft nephrectomies demonstrating CAN, obtained from patients with irreversible transplant kidney failure (n = 15), were compared with renal tissues without prominent histopathological abnormalities (n = 18) and a series of renal allograft biopsies demonstrating acute vascular rejection (AVR) (n = 12). Antibodies to PDGF-D and PDGF-Rbeta were used for immunohistochemistry. Double and triple immunohistochemistry was used to identify cell types expressing PDGF-D. PDGF-D was widely expressed in most neointimas in arteries exhibiting the chronic arteriopathy of CAN and only weakly expressed in a small proportion of sclerotic arteries in the other 2 groups. Double and triple immunolabeling de...Continue Reading

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Citations

Apr 10, 2009·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Peter BoorJürgen Floege
Feb 5, 2014·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Peter BoorJürgen Floege
Jun 28, 2014·BioMed Research International·Badri Man Shrestha, John Haylor
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Aug 28, 2015·Kidney International Supplements·Tammo OstendorfJürgen Floege
Feb 19, 2015·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·P Boor, J Floege
Aug 30, 2011·European Journal of Cell Biology·Claudia R C van RoeyenJürgen Floege
May 21, 2011·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Tammo OstendorfJürgen Floege

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