Identification of possible sources of nanotoxicity from carbon nanotubes inserted into membrane bilayers using membrane interaction quantitative structure--activity relationship analysis

Chemical Research in Toxicology
Jianzhong Liu, Anton J Hopfinger

Abstract

Four possible sources of cellular toxicity due to the insertion of a carbon nanotube into a dimyristoylphosphatidylcholine (DMPC) membrane bilayer were explored using the membrane interaction quantitative structure-activity relationship methodology. Comparisons of (i) the structural organization of the membrane bilayer, (ii) dynamical features of the membrane bilayer, and (iii) transport of small polar molecules across the membrane bilayer were carried out with, and without, a carbon nanotube inserted into the bilayer. A fourth study was performed to determine how the transport of solvated ions through the inserted nanotube might alter the structure of the membrane bilayer. Two large changes in the bilayer occur due to insertion of the carbon nanotube. First, there is an alteration in the packing of the DMPC bilayer molecules, which extends at least 18 A from the nanotube, and includes the creation of a relatively open, unoccupied cylindrical ring of 2-4 A thickness directly around the nanotube. Second, the same bilayer structure, which undergoes the change in structural organization, also becomes much more rigid than when the nanotube is not inserted. Solvated calcium ions are predicted to preferentially transport through the ...Continue Reading

Citations

Sep 23, 2010·ACS Nano·Denis FourchesAlexander Tropsha
Jul 8, 2014·Drug Discovery Today·Orazio NicolottiEttore Novellino
Jun 6, 2012·Advanced Drug Delivery Reviews·Agnieszka GajewiczJerzy Leszczynski
Mar 5, 2016·ACS Nano·Rebeca Garcia-FandiñoMark S P Sansom
Mar 9, 2011·Wiley Interdisciplinary Reviews. Nanomedicine and Nanobiotechnology·Enrico Burello, Andrew P Worth
Jun 22, 2010·Risk Analysis : an Official Publication of the Society for Risk Analysis·Christie Sayes, Ivan Ivanov
Sep 8, 2010·Environmental Toxicology and Chemistry·Ki T KimSang D Kim
May 27, 2011·Journal of Liposome Research·Jernej ZupancBranko Ster
Feb 16, 2010·Nanotechnology·Xiao Chen, Hermann J Schluesener
Sep 14, 2019·Annual Review of Pharmacology and Toxicology·Hao Zhu
Apr 21, 2012·The Journal of Physical Chemistry. B·Xiaoyi LiYuliang Zhao

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