Identification of postentry restrictions to Mason-Pfizer monkey virus infection in New World monkey cells

Journal of Virology
William DiehlEric Hunter

Abstract

TRIM5alpha has been shown to be a major postentry determinant of the host range for gammaretroviruses and lentiviruses and, more recently, spumaviruses. However, the restrictive potential of TRIM5alpha against other retroviruses has been largely unexplored. We sought to determine whether or not Mason-Pfizer monkey virus (M-PMV), a prototype betaretrovirus isolated from rhesus macaques, was sensitive to restriction by TRIM5alpha. Cell lines from both Old World and New World primate species were screened for their susceptibility to infection by vesicular stomatitis virus G protein pseudotyped M-PMV. All of the cell lines tested that were established from Old World primates were found to be susceptible to M-PMV infection. However, fibroblasts established from three New World monkey species specifically resisted infection by this virus. Exogenously expressing TRIM5alpha from either tamarin or squirrel monkeys in permissive cell lines resulted in a block to M-PMV infection. Restriction in the resistant cell line of spider monkey origin was determined to occur at a postentry stage. However, spider monkey TRIM5alpha expression in permissive cells failed to restrict M-PMV infection, and interference with endogenous TRIM5alpha in the sp...Continue Reading

References

Aug 1, 1977·Journal of Virology·D ColcherJ Schlom
Feb 1, 1978·Proceedings of the National Academy of Sciences of the United States of America·G J TodaroB Fleckenstein
Nov 1, 1975·Proceedings of the National Academy of Sciences of the United States of America·R Michalides, J Schlom
Jan 5, 1972·Nature: New Biology·R M McAllisterL Vernon
Mar 1, 1974·Nature·R E BenvenisteS S Kalter
Sep 1, 1968·Journal of Invertebrate Pathology·G H BergoldK Munz
Sep 1, 1968·Journal of Virology·C Wallis, J L Melnick
Nov 1, 1995·The Journal of General Virology·R ShibataA Adachi
Dec 24, 1996·Proceedings of the National Academy of Sciences of the United States of America·J ReiserM Schubert
Feb 7, 1998·Proceedings of the National Academy of Sciences of the United States of America·A TakadaY Kawaoka
Sep 2, 1999·Current Biology : CB·M BarbulescuJ Lenz
Oct 24, 2000·Journal of Virology·J ReiserR O Brady
Oct 10, 2001·Current Biology : CB·G TurnerJ Lenz
May 7, 2002·Molecular Therapy : the Journal of the American Society of Gene Therapy·Xian-Yang ZhangJakob Reiser
Aug 3, 2002·Proceedings of the National Academy of Sciences of the United States of America·Simone CowanPaul D Bieniasz
Jun 26, 2003·Methods in Molecular Biology·Michael P MarinoJakob Reiser
Feb 6, 2004·Proceedings of the National Academy of Sciences of the United States of America·Jennifer F Hughes, John M Coffin
May 14, 2004·Journal of Virology·Masahiro Yamashita, Michael Emerman
Jul 14, 2004·Proceedings of the National Academy of Sciences of the United States of America·Theodora HatziioannouPaul D Bieniasz
Jul 14, 2004·Proceedings of the National Academy of Sciences of the United States of America·Zuzana KeckesovaGreg J Towers
Jul 14, 2004·Proceedings of the National Academy of Sciences of the United States of America·Melvyn W YapJonathan P Stoye
Jul 29, 2004·Proceedings of the National Academy of Sciences of the United States of America·Michel J PerronJoseph Sodroski
Aug 25, 2004·Proceedings of the National Academy of Sciences of the United States of America·Sébastien NisoleMelvyn W Yap
Jan 15, 2005·Current Biology : CB·Melvyn W YapJonathan P Stoye
Feb 4, 2005·Proceedings of the National Academy of Sciences of the United States of America·Sara L SawyerHarmit S Malik
Mar 16, 2005·Journal of Virology·Byeongwoon SongJoseph Sodroski
Oct 29, 2005·Journal of Virology·Claudia C MischeJoseph Sodroski
Mar 17, 2006·Proceedings of the National Academy of Sciences of the United States of America·Matthew StremlauJoseph Sodroski

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Citations

Mar 13, 2012·Nature Structural & Molecular Biology·Matthew E C CainesLeo C James
Aug 22, 2009·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Stuart Neil, Paul Bieniasz
Aug 14, 2013·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Melvyn W Yap, Jonathan P Stoye
Mar 29, 2013·Journal of Virology·Sadayuki Ohkura, Jonathan P Stoye
Aug 31, 2013·PLoS Pathogens·Fan WuVanessa M Hirsch
Mar 8, 2014·PLoS Pathogens·Melvyn W YapJonathan P Stoye
Feb 25, 2009·Immunogenetics·Welkin E Johnson, Sara L Sawyer
Nov 26, 2009·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·Esmeralda A SoaresHector N Seuánez
Jun 17, 2009·Journal of Molecular Biology·Pavel MacekVladimír Sklenár
Nov 15, 2008·Journal of Molecular Biology·Gulnahar B MortuzaIan A Taylor
Dec 30, 2014·Journal of Virology·Gary Z Wang, Stephen P Goff
Jan 23, 2015·Journal of Virology·Rokusuke YoshikawaTakayuki Miyazawa
Sep 19, 2018·Proceedings of the National Academy of Sciences of the United States of America·George R YoungJonathan P Stoye

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