Identification of potent chromone embedded [1,2,3]-triazoles as novel anti-tubercular agents

Royal Society Open Science
Viswanadh NallaM Muthukrishnan

Abstract

A series of 20 novel chromone embedded [1,2,3]-triazoles derivatives were synthesized via an easy and convenient synthetic procedure starting from 2-hydroxy acetophenone. The in vitro anti-mycobacterial evaluation studies carried out in this work reveal that seven compounds exhibit significant inhibition against Mycobacterium tuberculosis H37Rv strain with MIC in the range of 1.56-12.5 µg ml-1. Noticeably, compound 6s was the most potent compound in vitro with a MIC value of 1.56 µg ml-1. Molecular docking and chemoinformatics studies revealed that compound 6s displayed drug-like properties against the enoyl-acyl carrier protein reductase of M. tuberculosis further establishing its potential as a potent inhibitor.

References

Mar 29, 2000·Journal of Acquired Immune Deficiency Syndromes : JAIDS·M TumbarelloR Cauda
Jun 7, 2000·American Journal of Infection Control·J K Anastasi, B Capili
May 23, 2001·Protein Science : a Publication of the Protein Society·H Munier-LehmannG Labesse
May 14, 2003·Archives of Internal Medicine·Elizabeth L CorbettChristopher Dye
Mar 19, 2004·Journal of Medicinal Chemistry·Thomas A HalgrenJay L Banks
Aug 15, 2006·Current Opinion in Pharmacology·Khisimuzi Mdluli, Melvin Spigelman
Feb 20, 2010·Proceedings of the National Academy of Sciences of the United States of America·Bo ZhouZhong-Yin Zhang
Jul 26, 2011·Journal of Medicinal Chemistry·Lorena TizónConcepción González-Bello
Apr 5, 2012·Dalton Transactions : an International Journal of Inorganic Chemistry·Kewal KumarVipan Kumar
Jan 19, 2013·Journal of Cheminformatics·Vincent Le GuillouxLuc Morin-Allory
Jan 30, 2013·Bioorganic & Medicinal Chemistry Letters·M MujahidM Muthukrishnan
Mar 28, 2013·Chemical Reviews·Prakasam ThirumuruganKrzysztof Jozwiak
Jun 14, 2013·Frontiers in Pharmacology·Andreas MaunzChristoph Helma
Jan 24, 2014·Journal of Chemical Information and Modeling·Alberto MassarottiGian Cesare Tron
Feb 22, 2014·Chemical Reviews·Alexandra GasparFernanda Borges
Apr 3, 2014·European Journal of Medicinal Chemistry·Rangappa S KeriR Geetha Balakrishna
Dec 3, 2014·Food Chemistry·Melliana JonathanHarry Gruppen
Feb 9, 2016·Journal of Natural Products·David J Newman, Gordon M Cragg
Nov 29, 2016·Drug Discovery Today·Maryline DongKarl-Heinz Altmann
May 26, 2017·Journal of Medicinal Chemistry·Joana ReisFernanda Borges
Jun 28, 2017·Proceedings of the National Academy of Sciences of the United States of America·Nitin P KaliaKevin Pethe
Jul 12, 2017·European Journal of Medicinal Chemistry·Shu ZhangLian-Shun Feng

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Citations

Aug 25, 2020·Pharmaceutical Chemistry Journal·Noor Ul Amin MohsinUsman Saleem
Sep 29, 2020·Bioorganic & Medicinal Chemistry Letters·Pramod S PhatakKishan P Haval
Jul 27, 2021·Russian Chemical Bulletin = Izvestii︠a︡ Akademii Nauk. Serii︠a︡ Khimicheskai︠a︡·S S ShatokhinÉ T Oganesyan

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Methods Mentioned

BETA
NMR
column chromatography

Software Mentioned

Lazy relationships ( LAZAR )
Screening Assistant
LigPrep
PreADMET
Protein Preparation Wizard Maestro
OPLS
Glide

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