Abstract
Triple-negative breast cancer (TNBC) is a subtype of breast cancer with poor clinical outcome and limited treatment options. Lacking molecular targets, chemotherapy is the main adjuvant treatment for TNBC patients. To explore potential therapeutic targets for TNBC, we analyzed three microarray datasets (GSE38959, GSE45827, and GSE65194) derived from the Gene Expression Omnibus (GEO) database. The GEO2R tool was used to screen out differentially expressed genes (DEGs) between TNBC and normal tissue. Gene Ontology function and Kyoto Encyclopedia of Genes and Genomes pathway enrichment analysis were performed using the Database for Annotation, Visualization and Integrated Discovery to identify the pathways and functional annotation of DEGs. Protein-protein interaction of these DEGs was analyzed based on the Search Tool for the Retrieval of Interacting Genes database and visualized by Cytoscape software. In addition, we used the online Kaplan-Meier plotter survival analysis tool to evaluate the prognostic value of hub genes expression in breast cancer patients. A total of 278 upregulated DEGs and 173 downregulated DEGs were identified. Among them, ten hub genes with a high degree of connectivity were picked out. Overexpression of t...Continue Reading
Citations
Mar 16, 2019·Cancers·Ishita GuptaAla-Eddin Al Moustafa
Sep 29, 2020·OncoTargets and Therapy·Chen ChenSheng Li
Mar 22, 2019·BioMed Research International·Sheng WangKe-Qun Chai
Aug 22, 2020·Cancer Management and Research·Lifei MaJiao Mu
Apr 25, 2020·Cells·Damiano Cosimo RigiraccioloMarcello Maggiolini
Sep 9, 2020·Scientific Reports·Mohammed Moustapha AnwarAhmed Hussein
May 28, 2019·Frontiers in Genetics·Xin YanSheng Li
Jul 1, 2020·Frontiers in Oncology·Bin ZhaoQiang Sun
May 3, 2020·Medicine·Jiarui ChenJian Zeng
Jul 26, 2019·BioMed Research International·Siying HeGuohua Yang
Nov 17, 2019·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Jun-Rong WuXue Qin
Oct 30, 2020·Cancer Management and Research·Shengnan WangJianjun Dong
Dec 11, 2020·BioMed Research International·Yuting XuFang Zheng
Feb 14, 2021·Medicine·Cheng-Lin QiShi-Ming Chen
Mar 11, 2021·Cancer Management and Research·Liqi LiJunqiang Wu
Apr 8, 2021·Clinical and Experimental Medicine·Minya YaoPeifen Fu
May 14, 2021·Bioscience Reports·Mengmeng WangKe Du
Jun 1, 2021·BMC Cancer·Yiduo LiuLei Bi
Aug 20, 2021·Annals of Medicine·Zhenzhen Lu, Ying Gao
Aug 23, 2021·BMC Infectious Diseases·Weina Lu, Ran Ji
Nov 5, 2021·American Journal of Alzheimer's Disease and Other Dementias·Yajing ChengFei Wang