Identification of Potential Diagnostic and Prognostic Values of P4HA1 Expression in Lung Cancer, Breast Cancer, and Head and Neck Cancer

DNA and Cell Biology
Mingjie LiYan'an Wu

Abstract

The aims of this study were to investigate the expression of prolyl 4-hydroxylase subunit alpha-1 (P4HA1) and its relationship with clinicopathological features in lung cancer (LC), breast cancer (BC), and head and neck cancer (HNSC) and to discuss the possibility of P4HA1 being a potential diagnostic and prognostic biomarker. Data on the RNA expression profile, protein expression profile, and relevant clinical information were downloaded from The Cancer Genome Atlas (TCGA) and The Human Protein Atlas databases. The relationship between P4HA1 mRNA expression and clinicopathological features was evaluated. Survival analysis was performed to assess overall survival (OS) and relapse-free survival (RFS). The multivariate Cox regression model was employed to analyze the independent prognostic factors. Finally, protein-protein interaction networks were constructed and enrichment analysis was performed to identify the latent P4HA1-related terms and pathways. This study showed that P4HA1 was upregulated in three types of tumor tissues (p < 0.05) and high P4HA1 was significantly relevant to the clinical features of patients with LC, BC, or HNSC. Survival analysis indicated that patients with high P4HA1 had unfavorable clinical outcomes....Continue Reading

References

Apr 26, 2003·Matrix Biology : Journal of the International Society for Matrix Biology·Johanna Myllyharju
Sep 23, 2003·The Journal of Biological Chemistry·Liisa KukkolaJohanna Myllyharju
Oct 6, 2010·Advances in Genetics·Marta Kulis, Manel Esteller
Feb 22, 2012·The Journal of Cell Biology·Pengfei LuZena Werb
Aug 1, 2012·The Lancet Oncology·Milena Maule, Franco Merletti
Feb 20, 2013·Journal of Cell Science·Frances R BalkwillThorsten Hagemann
Mar 30, 2013·Cancer Research·Daniele M GilkesGregg L Semenza
Aug 15, 2014·Oncotarget·Balabhadrapatruni V S K ChakravarthiSooryanarayana Varambally
Feb 5, 2016·Cancer Letters·Ting Wu, Yun Dai
Mar 12, 2016·Biochemical and Biophysical Research Communications·Guoxing FengXiaodong Zhang
Jan 28, 2017·Matrix Biology : Journal of the International Society for Matrix Biology·Liliana GuerraDaniele Castiglia
Oct 2, 2017·Pathology, Research and Practice·Wan-Ming HuKe Sai
Aug 24, 2018·Cell Biology International·Yanan DuanJianxin Cheng
Jul 28, 2019·Nature Reviews. Molecular Cell Biology·Ernesto Guccione, Stéphane Richard

❮ Previous
Next ❯

Citations

May 28, 2020·DNA and Cell Biology·Yun-Hua XuGuo Wang
May 29, 2021·Translational Oncology·Alyncia D RobinsonSooryanarayana Varambally
Jul 5, 2021·Cancer Cell International·Yang YangLan Zhang

❮ Previous
Next ❯

Software Mentioned

TCGAbiolinks
KOBAS
Bioconductor
MethSurv
Cytoscape
SPSS

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.