Identification of potential human urinary biomarkers for tomato juice intake by mass spectrometry-based metabolomics

European Journal of Nutrition
Yannick HövelmannHans-Ulrich Humpf

Abstract

Dietary biomarkers allow the accurate and objective determination of the dietary intake of humans and can thus be valuable for investigating the relation between consumption of foods and biochemical as well as physiological responses. The objective of this study was the identification of potential urinary biomarkers for consumption of tomato juice. In the course of a dietary intervention study, the human urine metabolome of a study cohort was compared between a tomato-free diet and after intake of tomato juice by application of an LC-HRMS-based metabolomics approach. The data acquisition was achieved using an orbitrap mass spectrometer, followed by multistage data processing and univariate as well as multivariate statistical analysis to identify discriminating features. Statistical analysis revealed several unique features detectable after tomato juice intake. The most discriminating markers were putatively identified as hydroxylated and sulfonated metabolites of esculeogenin B, aglycone of the steroidal glycoalkaloid esculeoside B recently found in tomato juice. Furthermore, the β-carboline alkaloids tangutorid E and F and glucuronidated derivatives thereof were identified in urine. Steroidal glycoalkaloids in tomato juice are...Continue Reading

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Citations

May 19, 2019·Nutrients·Catalina PicóAndreu Palou
Jul 9, 2020·Frontiers in Plant Science·Michael P DzakovichJessica L Cooperstone
May 10, 2020·Molecular Nutrition & Food Research·Yannick HövelmannHans-Ulrich Humpf
Mar 16, 2019·Journal of Agricultural and Food Chemistry·Yannick HövelmannHans-Ulrich Humpf
Mar 13, 2019·Journal of Agricultural and Food Chemistry·Yannick HövelmannHans-Ulrich Humpf

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