Identification of potential molecular mechanisms and small molecule drugs in myocardial ischemia/reperfusion injury

Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas
Tao JiangLiangyi Si

Abstract

Myocardial ischemia/reperfusion (MI/R) injury is a complex phenomenon that causes severe damage to the myocardium. However, the potential molecular mechanisms of MI/R injury have not been fully clarified. We identified potential molecular mechanisms and therapeutic targets in MI/R injury through analysis of Gene Expression Omnibus (GEO) database. Differentially expressed genes (DEGs) were found between MI/R injury and normal samples, and overlapping DEGs were found between GSE61592 and GSE67308. Gene Ontology (GO) and pathway analysis were performed for overlapping DEGs by Database for Annotation, Visualization and Integration Discovery (DAVID). Then, a network of protein-protein interaction (PPI) was constructed through the Search Tool for the Retrieval of Interacting Genes (STRING) database. Potential microRNAs (miRNAs) and therapeutic small molecules were screened out using microRNA.org database and the Comparative Toxicogenomics database (CTD), respectively. Finally, we identified 21 overlapping DEGs related to MI/R injury. These DEGs were significantly enriched in IL-17 signaling pathway, cytosolic DNA-sensing pathway, chemokine signaling, and cytokine-cytokine receptor interaction pathway. According to the degree in the P...Continue Reading

References

Dec 11, 1999·Nucleic Acids Research·M Kanehisa, S Goto
Dec 26, 2007·Nucleic Acids Research·Doron BetelChris Sander
Jul 2, 2008·The British Journal of Nutrition·Alison M CoatesPeter R C Howe
Dec 5, 2009·European Journal of Pharmacology·Clara Di FilippoMichele D'Amico
Nov 26, 2010·Antioxidants & Redox Signaling·Meng-Ling WuShaw-Fang Yet
Feb 10, 2012·Basic Research in Cardiology·H Christian VolzMartin Andrassy
Mar 1, 2012·International Journal of Cardiology·Jacques BlacherUNKNOWN SU.FOL.OM3 Study Research Group
Dec 4, 2012·Nucleic Acids Research·Andrea FranceschiniLars J Jensen
May 13, 2015·Diabetes, Obesity & Metabolism·H FlorezUNKNOWN VADT Research Group
Jun 9, 2016·Proceedings of the National Academy of Sciences of the United States of America·Thor TejadaAhsan Husain
Dec 4, 2016·International Journal of Cardiology·Kuang-Hsing ChiangJu-Pin Pan
Feb 15, 2017·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Weixin MengHongyu Liu
Sep 25, 2018·Nucleic Acids Research·Allan Peter DavisCarolyn J Mattingly
Mar 8, 2019·Advances in Clinical and Experimental Medicine : Official Organ Wroclaw Medical University·Yuan YaoYao Zhang

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Citations

May 22, 2021·International Immunopharmacology·Salvatore ChirumboloSergio Pandolfi

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Datasets Mentioned

BETA
GSE61592
GSE67308

Software Mentioned

mirSVR
Geoquery
miRanda
Search Tool for the Retrieval of Interacting Genes ( STRING

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