Identification of prenatal amphetamines exposure by maternal interview and meconium toxicology in the Infant Development, Environment and Lifestyle (IDEAL) study.

Therapeutic Drug Monitoring
Teresa R GrayMarilyn A Huestis

Abstract

The Infant Development Environment and Lifestyle study is investigating the effects of prenatal methamphetamine (MAMP) exposure on infant and child development; potential concurrent exposure to cannabis and tobacco also are evaluated. Maternal self-reported drug use and/or meconium toxicology results defined drug exposure status. It is unclear how the frequency, duration, and magnitude of maternal MAMP exposure affect qualitative and quantitative meconium results. Interviews regarding maternal drug use were collected shortly after birth; meconium specimens were screened for amphetamines, cannabis, and cotinine by immunoassay and confirmed by gas chromatography mass spectrometry. The majority of MAMP- and cannabis-exposed infants were identified by maternal interview alone. Meconium tests were more likely to be positive if the mother reported MAMP and cannabis use, particularly in the third trimester. Less than half of immunoassay-positive amphetamines (31.0%) and cannabis (17.9%) meconium results were confirmed by gas chromatography mass spectrometry. Tobacco exposure was equally detected by immunoassay cotinine screening and maternal report. Meconium concentrations did not correlate with maternal self-report status or trimeste...Continue Reading

References

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Mar 21, 2007·Analytical and Bioanalytical Chemistry·Teresa Gray, Marilyn Huestis
Nov 23, 2007·Neurotoxicology and Teratology·Lynne M SmithBarry M Lester
Jan 7, 2009·Therapeutic Drug Monitoring·Teresa R GrayMarilyn A Huestis

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Citations

Apr 30, 2010·Nicotine & Tobacco Research : Official Journal of the Society for Research on Nicotine and Tobacco·Teresa R GrayMarilyn A Huestis
Dec 15, 2010·Journal of Perinatology : Official Journal of the California Perinatal Association·T E WrightA C Collier
Feb 9, 2018·Therapeutic Drug Monitoring·Simuli L WabuyeleGwendolyn A McMillin
Aug 3, 2018·Development and Psychopathology·Laura R StroudAmy L Salisbury
Jun 15, 2014·Journal of Analytical Toxicology·Kelly E WoodGwendolyn A McMillin
Jan 8, 2015·Therapeutic Drug Monitoring·Gwendolyn A McMillinMatthew D Krasowski
Sep 30, 2018·Neurotoxicology and Teratology·Laura R StroudMarilyn A Huestis
Apr 9, 2021·Addiction·Fatima Anne PerezJu Lee Oei
Nov 13, 2020·Journal of Addiction Medicine·Sarah Meyers, Elisha M Wachman
Apr 25, 2012·Reproductive Toxicology·S OrtigosaO Garcia-Algar

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