PMID: 2994790Aug 1, 1985

Identification of presynaptic beta 2-adrenoceptors on the sympathetic nerve fibres of the human pulmonary artery

British Journal of Pharmacology
M Göthert, F Hentrich

Abstract

Strips of human pulmonary arteries from patients undergoing surgery for lung tumour were incubated with [3H]-noradrenaline. Subsequently, they were superfused with physiological salt solution containing cocaine and corticosterone. Tritium overflow from the strips was stimulated by transmural electrical impulses (2 Hz). The electrically evoked overflow of tritium consisted of 91% unmetabolized [3H]-noradrenaline, and this percentage was not altered by isoprenaline. Adrenaline (in the presence of rauwolscine), isoprenaline and the preferential beta 2-adrenoceptor agonist, procaterol, concentration-dependently increased the electrically evoked tritium overflow. Prenalterol, a beta-adrenoceptor agonist with moderate preference for beta 1-adrenoceptors, was considerably less active than the previously mentioned agonists; noradrenaline (in the presence of rauwolscine) was ineffective. The concentration-response curve of procaterol was shifted to the right by the preferential beta 2-adrenoceptor antagonist ICI 118-551 but was not affected by the beta 1-selective antagonist, atenolol. Propranolol, but not atenolol, produced a shift to the right of the concentration-response curve of isoprenaline. It is concluded that the sympathetic ne...Continue Reading

References

Mar 1, 1976·Acta Physiologica Scandinavica·L Stjärne, J Brundin
Jan 1, 1977·Reviews of Physiology, Biochemistry and Pharmacology·K Starke
Nov 10, 1977·Naunyn-Schmiedeberg's Archives of Pharmacology·E CarlssonB Tångstrand
Dec 7, 1979·European Journal of Pharmacology·S R NahorskiP Redgrave
Nov 1, 1978·Naunyn-Schmiedeberg's Archives of Pharmacology·S GuimarãesM Q Paiva
Feb 1, 1977·Naunyn-Schmiedeberg's Archives of Pharmacology·T EndoH D Taube
Feb 10, 1967·Annals of the New York Academy of Sciences·R F Furchgott
Sep 1, 1980·The Journal of Pharmacy and Pharmacology·U Johansson, B Waldeck
Sep 24, 1982·European Journal of Pharmacology·M J StevensR F Moulds
Jan 1, 1983·General Pharmacology·R F Moulds, M J Stevens
Jul 13, 1984·European Journal of Pharmacology·M GöthertH R Zerkowski
Jan 1, 1980·British Journal of Pharmacology·H MajewskiD F Story
Jan 1, 1981·Annual Review of Pharmacology and Toxicology·K Starke
May 1, 1982·British Journal of Clinical Pharmacology·H H VincentM A Schalekamp
Sep 1, 1981·Journal of Applied Physiology: Respiratory, Environmental and Exercise Physiology·W K FreemanG M Tyce

Citations

Feb 1, 1991·Naunyn-Schmiedeberg's Archives of Pharmacology·J Abrahamsen, O A Nedergaard
Apr 1, 1986·Naunyn-Schmiedeberg's Archives of Pharmacology·M GöthertH R Zerkowski
Sep 1, 1985·Naunyn-Schmiedeberg's Archives of Pharmacology·F HentrichD Greschuchna
May 3, 2013·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Myron C GersonArnold F Jacobson
Mar 17, 1992·European Journal of Pharmacology·M A MianM J Rand
Oct 18, 2000·European Journal of Pharmacology·A D KraneveldF P Nijkamp
Apr 4, 2006·The Journal of Physiology·Eun Joo OhDaniel Weinreich
May 20, 2003·Pharmacology & Toxicology·M Göthert
Jan 1, 1992·Hypertension·J S Floras
Jan 1, 1988·Pharmacology & Toxicology·M Göthert
Jan 1, 1990·Annals of the New York Academy of Sciences·O A Nedergaard, J Abrahamsen
Jan 1, 1988·Pharmacology & Toxicology·J Abrahamsen, O A Nedergaard
May 31, 2003·American Journal of Physiology. Heart and Circulatory Physiology·Alejandro N MazzadiMarc Janier

Related Concepts

ICI 118551, hydrochloride
Cocaine Hydrochloride
Corticosterone
Dose-Response Relationship, Drug
Electric Stimulation Technique
Ethanolamines
Novodrin
Mathematics
Cerebellar Mossy Fibers
Norepinephrine, (+, -)-Isomer

Related Feeds

Adrenergic Receptors: Trafficking

Adrenergic receptor trafficking is an active physiological process where adrenergic receptors are relocated from one region of the cell to another or from one type of cell to another. Discover the latest research on adrenergic receptor trafficking here.