Identification of primary tumour site by immunolocalization of progastricsin in metastatic adenocarcinoma

The Journal of Pathology
W A ReidJ Kay

Abstract

The aspartic proteinase zymogen, progastricsin, which occurs in normal gastroduodenal mucosa and prostate, has been localized by the immunogold-silver method in formalin-fixed, paraffin-embedded sections of metastatic adenocarcinoma in lymph nodes and liver, the primary site being known in each case. Progastricsin was demonstrated in 16 of 84 lymph node metastases, including 7 of 17 from stomach, 2 of 2 from prostate, and 7 of 65 from other sites. Progastricsin was also found in 19 of 98 hepatic metastases, including 8 of 22 from stomach, 6 of 24 from pancreas, and 5 of 52 from other sites. The presence of progastricsin in a metastasis correlated well with a primary tumour in the stomach or prostate or, less significantly, pancreas. Immunolocalization of progastricsin in a histological section of metastatic adenocarcinoma may help to locate the primary site.

References

Oct 1, 1988·Journal of Clinical Pathology·I O Ellis, A Hitchcock
Sep 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·R T TaggartG I Bell
Jun 1, 1985·Journal of Clinical Pathology·W A ReidJ Kay
Jan 1, 1980·Virchows Archiv. A, Pathological Anatomy and Histology·W BöckerM Brassow

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Citations

Jan 30, 1993·BMJ : British Medical Journal·A R GambleI O Ellis
Apr 1, 1994·Cancer Treatment Reviews·G Daugaard
Oct 3, 1998·Equine Veterinary Journal·A Garma-Aviña

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