Identification of prognostic and subtype-specific potential miRNAs in thymoma

Epigenomics
Jiamin WeiJianhua Lin

Abstract

We performed a study to identify the role of microRNA in thymoma. One hundred twenty-three thymoma patients with clinical information and miRNA expression data from The Cancer Genome Atlas were included in the study. Comprehensive bioinformatics analysis was integrated in our analysis. Seven miRNAs were found to be associated with overall survival (p < 0.001). Another four miRNAs were found to be associated with disease-free survival (p < 0.001). Type C thymoma can be distinguished from nontype C thymoma by miRNAs. Interestingly, seven miRNAs showed both prognostic and subtype-specific potential. Our findings suggest that miRNAs can be used for prognostic prediction and subtype stratification.

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Software Mentioned

DIANA
BRB
miRPath
miPath
ArrayTools Development Team
ArrayTools
R language
microT

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