PMID: 9051728Jan 1, 1997Paper

Identification of prokaryotic and eukaryotic signal peptides and prediction of their cleavage sites

Protein Engineering
H NielsenG von Heijne


We have developed a new method for the identification of signal peptides and their cleavage sites based on neural networks trained on separate sets of prokaryotic and eukaryotic sequence. The method performs significantly better than previous prediction schemes and can easily be applied on genome-wide data sets. Discrimination between cleaved signal peptides and uncleaved N-terminal signal-anchor sequences is also possible, though with lower precision. Predictions can be made on a publicly available WWW server.


Oct 15, 1998·Molecular Reproduction and Development·K E Mate, C A McCartney
Feb 13, 2001·European Journal of Immunology·K C BeierR A Kroczek
Dec 26, 2001·European Journal of Immunology·Ludmila V MechetinaAlexander V Taranin
Jul 17, 2008·Comparative and Functional Genomics·Carl MayersRichard W Titball
Jul 31, 2001·Genesis : the Journal of Genetics and Development·E W KleeL B Ellis
May 6, 1998·Protein Science : a Publication of the Protein Society·E Wallin, G von Heijne
Dec 10, 2002·Proteins·Marco Punta, Amos Maritan
Jul 5, 2001·Archives of Biochemistry and Biophysics·M G SoarsB Burchell
Dec 19, 2001·Archives of Biochemistry and Biophysics·V Bracchi-RicardD Pei
Feb 16, 2000·Biochemical and Biophysical Research Communications·O RøsokH C Aasheim
Mar 18, 2000·Biochemical and Biophysical Research Communications·B StrukeljM A Jongsma
May 18, 2000·Biochemical and Biophysical Research Communications·K ShibuyaN Shimizu
Jun 30, 2000·Biochemical and Biophysical Research Communications·C LenzC J Grimmelikhuijzen
Jul 13, 2000·Biochemical and Biophysical Research Communications·C LenzC J Grimmelikhuijzen
Oct 12, 2000·Biochemical and Biophysical Research Communications·S ApparsundaramR D Blakely
Oct 18, 2000·Biochemical and Biophysical Research Communications·S OhmachiN Itoh
Mar 27, 2001·Biochemical and Biophysical Research Communications·M Maïbèche-CoisneC Dauphin-Villemant
Mar 27, 2001·Biochemical and Biophysical Research Communications·M WilliamsonC J Grimmelikhuijzen
May 18, 2001·Biochemical and Biophysical Research Communications·A R TanakaK Ueda
Jun 23, 2000·Experimental Parasitology·R CharlabJ M Ribeiro
Jun 15, 2007·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Shuo Cheng ZhangPaul R Murphy
May 30, 2009·TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik·Jessica EndrigkeitChristian Jung
Nov 20, 2004·Archives of Microbiology·Ralf RabusRichard Reinhardt
Jan 25, 2006·Archives of Microbiology·Renu SrivastavaEva-Mari Aro
Jun 7, 2006·Journal of Molecular Evolution·Nina M Talyzina, Pär K Ingvarsson
Oct 17, 2007·Journal of Molecular Evolution·Katerina JiroutováMiroslav Oborník
Oct 16, 2012·Journal of Molecular Evolution·Katarína KrnáčováAnton Horváth
Nov 13, 2004·Applied Microbiology and Biotechnology·André O S LimaJoão L Azevedo
Sep 30, 2005·Applied Microbiology and Biotechnology·Hans P SørensenMads G Johnsen

❮ Previous
Next ❯

Related Concepts

Trending Feeds


Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.


Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.


Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.