Identification of prostaglandin E2 receptors mediating perinatal masculinization of adult sex behavior and neuroanatomical correlates.

Developmental Neurobiology
Christopher L WrightM M McCarthy

Abstract

Prostaglandin E2 (PGE2) mediates the organization of male rat sexual behavior and medial preoptic area (MPOA) neuroanatomy during a sensitive perinatal window. PGE2 is up-regulated in response to estradiol, and initiates a two-fold increase in dendritic spines densities on neurons. All the four receptors for PGE2 and EP1-4 are present in developing POA, a critical region controlling male sexual behavior. Previous studies explored that EP receptors are involved in PGE2-induction of neonatal levels of spinophilin protein, a surrogate marker for dendritic spine formation, but did not assess behavioral masculinization. Here, we used two approaches, suppression of EP receptor expression with antisense oligonucleotides and activation of EP receptors with selective agonists, to test which receptors are necessary and sufficient, respectively, for the effects of PGE2 on behavior and neuronal morphology. In female rats, neonatal treatment with antisense oligonucleotides against EP2 or EP4 but not EP1 or EP3 completely prevented the expression of adult behavior organized by PGE2 exposure. The effects of ONO-DI-004, ONO-AE-259-01, ONO-AE-248, and ONO-AE1-329 (EP1-4 agonists respectively) were equivalent to PGE2 treatment, which suggests ac...Continue Reading

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Citations

May 27, 2011·Nature Neuroscience·Margaret M McCarthy, Arthur P Arnold
Aug 25, 2009·The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry·Margaret M McCarthy
Oct 23, 2009·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Christopher L Wright, Margaret M McCarthy
Jan 23, 2016·Frontiers in Neuroendocrinology·Nancy G ForgerAlexandra Castillo-Ruiz
Sep 18, 2012·Journal of Pharmacological and Toxicological Methods·Blase BillackCraig H Kinsley
Mar 6, 2012·Hormones and Behavior·Jaclyn M Schwarz, Staci D Bilbo
Sep 4, 2010·Trends in Endocrinology and Metabolism : TEM·Christopher L WrightMargaret M McCarthy
May 19, 2009·Hormones and Behavior·Geert J de Vries, Per Södersten
Oct 24, 2015·Neuroscience Letters·Shunji YamadaMitsuhiro Kawata
Apr 29, 2015·Hormones and Behavior·Margaret M McCarthyKatherine E Kight
Apr 20, 2012·The European Journal of Neuroscience·Shannon L DeanMargaret M McCarthy
Jul 22, 2010·Journal of Neuroendocrinology·M M McCarthy
Mar 31, 2015·Nature Neuroscience·Bridget M NugentMargaret M McCarthy
Jun 24, 2017·Nature Reviews. Neuroscience·Margaret M McCarthyKathryn M Lenz
Dec 21, 2017·Scientific Reports·Arnaud JeanHelene Hardin-Pouzet
Dec 16, 2017·Developmental Neurobiology·Jonathan W VanRyzinMargaret M McCarthy
Nov 11, 2019·Journal of Comparative Physiology. A, Neuroethology, Sensory, Neural, and Behavioral Physiology·Margaret M McCarthy
Apr 10, 2020·Endocrinology·Sheryl E Arambula, Margaret M McCarthy
May 30, 2014·The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry·Kathryn M Lenz, Margaret M McCarthy
Jun 5, 2020·International Journal of Molecular Sciences·Diana LupuJoëlle Rüegg
Aug 28, 2020·Frontiers in Neuroscience·Shinji Tsukahara, Masahiro Morishita
May 1, 2018·Frontiers in Immunology·Kathryn M Lenz, Lars H Nelson
Aug 25, 2019·Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology·Luciane H GargaglioniLuis Gustavo A Patrone
Dec 31, 2017·Frontiers in Neuroendocrinology·Jennifer R RainvilleGeorgia E Hodes

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