Identification of proteins found to be significantly altered when comparing the serum proteome from Multiple Myeloma patients with varying degrees of bone disease

BMC Genomics
Paul DowlingPeter O'Gorman

Abstract

Bone destruction is a feature of multiple myeloma, characterised by osteolytic bone destruction due to increased osteoclast activity and suppressed or absent osteoblast activity. Almost all multiple myeloma patients develop osteolytic bone lesions associated with severe and debilitating bone pain, pathologic fractures, hypercalcemia, and spinal cord compression, as well as increased mortality. Biomarkers of bone remodelling are used to identify disease characteristics that can help select the optimal management of patients. However, more accurate biomarkers are needed to effectively mirror the dynamics of bone disease activity. A label-free mass spectrometry-based strategy was employed for discovery phase analysis of fractionated patient serum samples associated with no or high bone disease. A number of proteins were identified which were statistically significantly correlated with bone disease, including enzymes, extracellular matrix glycoproteins, and components of the complement system. Enzyme-linked immunosorbent assay of complement C4 and serum paraoxonase/arylesterase 1 indicated that these proteins were associated with high bone disease in a larger independent cohort of patient samples. These biomolecules may therefore b...Continue Reading

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Citations

Jan 21, 2016·British Journal of Haematology·Kay R TingPeter O'Gorman
Oct 25, 2016·International Journal of Molecular Sciences·Philip EganH Denis Alexander
Apr 29, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Marta MuszyńskaElżbieta Skrzydlewska
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Dec 8, 2016·Annals of Hematology·Fengjuan JiangRong Fu
Jan 1, 2020·Expert Review of Precision Medicine and Drug Development·Matthew HoKenneth C Anderson

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Methods Mentioned

BETA
imaging techniques
ELISA

Software Mentioned

Xcalibur
Progenesis
Progenesis LC - MS
Proteominer
MedCalc
STRING
MASCOT
STRING ( Search Tool for the Retrieval of Interacting Genes )
Progenesis free -

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