Identification of quantitative trait loci affecting murine long bone length in a two-generation intercross of LG/J and SM/J Mice.

Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research
Elizabeth A NorgardJames M Cheverud

Abstract

Study of mutations with large phenotypic effects has allowed the identification of key players in skeletal development. However, the molecular nature of variation in large, phenotypically normal populations tends to be characterized by smaller phenotypic effects that remain undefined. We use interval mapping and quantitative trait locus (QTL) mapping techniques in the combined F2-F3 populations (n = 2111) of an LG/J x SM/J mouse intercross to detect QTLs associated with the lengths of the humerus, ulna, femur, and tibia. Seventy individual trait QTLs affecting long bone lengths were detected, with several chromosomes harboring multiple QTLs. The genetic architecture suggests mainly small, additive effects on long bone length, with roughly one third of the QTLs displaying dominance. Sex interactions were common, and four sex-specific QTLs were observed. Pleiotropy could not be rejected for most of the QTLs identified. Thirty-one epistatic interactions were detected, almost all affecting regions including or immediately adjacent to QTLs. A complex regulatory network with many gene interactions modulates bone growth, possibly with integrated skeletal modules that allow fine-tuning of developmental processes present. Candidate gene...Continue Reading

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Citations

Apr 24, 2008·Genetics·Jane P Kenney-HuntJames M Cheverud
Mar 24, 2009·Mammalian Genome : Official Journal of the International Mammalian Genome Society·Elizabeth A NorgardJames M Cheverud
Apr 15, 2010·Journal of Lipid Research·James M CheverudClay F Semenkovich
Dec 21, 2010·Mammalian Genome : Official Journal of the International Mammalian Genome Society·Elizabeth A NorgardJames M Cheverud
Sep 26, 2013·Genome Biology and Evolution·Mihaela PavlicevJames M Cheverud
Oct 12, 2012·Mammalian Genome : Official Journal of the International Mammalian Genome Society·Carolina P GóesAndrea C Peripato
Mar 1, 2009·Evolutionary Biology·Katherine E WillmoreJoan T Richtsmeier
Dec 17, 2014·BMC Evolutionary Biology·Marta MarchiniCampbell Rolian
May 2, 2008·American Journal of Human Biology : the Official Journal of the Human Biology Council·David KarasikSerkalem Demissie
Mar 5, 2010·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Karl J JepsenJoseph H Nadeau
Jun 4, 2011·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Charles R FarberDaniel Pomp
Feb 18, 2011·Journal of Experimental Zoology. Part B, Molecular and Developmental Evolution·Thomas J SangerJames M Cheverud
Jan 26, 2012·Arthritis and Rheumatism·Muhammad Farooq RaiLinda J Sandell
Apr 5, 2011·Journal of Experimental Zoology. Part B, Molecular and Developmental Evolution·Mihaela PavlicevJames M Cheverud
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Jan 31, 2020·Wiley Interdisciplinary Reviews. Developmental Biology·Campbell Rolian
Feb 21, 2016·Genetics·Philipp MitteroeckerMihaela Pavlicev
Jun 3, 2010·Genetics·Mihaela PavlicevThomas F Hansen
Oct 4, 2016·Genetics·Michelle D ParmenterBret A Payseur
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Jan 14, 2017·G3 : Genes - Genomes - Genetics·Olivia L SabikCharles R Farber
Feb 10, 2021·G3 : Genes - Genomes - Genetics·Ricardo WilchesYingguang Frank Chan

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