Identification of rat prostatic steroid binding protein (PSBP) as an immunosuppressive factor

Journal of Reproductive Immunology
M MaccioniV E Rivero

Abstract

Prostatic steroid binding protein (PSBP) is the major protein produced ( approximately 20% of the total cytosolic protein) and secreted into the seminal fluid by the rat ventral prostate but its physiological function has not been elucidated yet. Since PSBP is secreted into the seminal fluid (which is itself a potent immunosuppressor) and has strong homology with uteroglobin (which possess an important anti-inflammatory function) our aim was to determine what effect, if any, PSBP would have on the immune system. With that purpose in mind we performed mononuclear cell cultures in the presence or absence of purified PSBP and analysed the effect of this protein on different functional parameters. PSBP inhibits the mitogen-induced proliferation of normal rat spleen mononuclear cells (MNC) specifically and in a dose-dependent manner. It reduces the production of IL-2 and the expression of its receptor (analysed by flow cytometry) which are important events for lymphocyte proliferation. Also, PSBP was able to inhibit OVA-specific proliferation of lymph node cells from previously primed animals. The immunosuppressive effect of PSBP is not due to an inherent toxic effect to the cells, since the cell viability was kept intact at the dif...Continue Reading

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Citations

Apr 10, 2002·Scandinavian Journal of Immunology·T R EschV A Levanos
Feb 22, 2007·Proceedings. Biological Sciences·Kenneth M FedorkaDaniel Promislow
Oct 31, 2002·American Journal of Respiratory and Critical Care Medicine·Susan D ReynoldsBarry R Stripp
Mar 4, 2006·Reproduction : the Official Journal of the Society for the Study of Fertility·Nadia GopichandranNicolas M Orsi
Jan 31, 2004·American Journal of Reproductive Immunology : AJRI·Mariana MaccioniVirginia E Rivero
Jan 3, 2013·Journal of Cellular Physiology·Carolina LeimgruberCristina Alicia Maldonado
Jan 23, 2015·Epigenetics : Official Journal of the DNA Methylation Society·Rebecca Lee Yean WongCheryl Lyn Walker
Mar 1, 2017·Cell Biology International·Amado A Quintar, Cristina A Maldonado
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Dec 25, 2013·Proceedings of the National Academy of Sciences of the United States of America·Oh-Joon KwonLi Xin
Feb 23, 2020·International Journal of Molecular Sciences·Cécile Bienboire-FrosiniPatrick Pageat
Apr 2, 2003·Development·Kyriakos D Economides, Mario R Capecchi

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