Identification of rice cornichon as a possible cargo receptor for the Golgi-localized sodium transporter OsHKT1;3

Journal of Experimental Botany
Paul Rosas-SantiagoOmar Pantoja

Abstract

Membrane proteins are synthesized and folded in the endoplasmic reticulum (ER), and continue their path to their site of residence along the secretory pathway. The COPII system has been identified as a key player for selecting and directing the fate of membrane and secretory cargo proteins. Selection of cargo proteins within the COPII vesicles is achieved by cargo receptors. The cornichon cargo receptor belongs to a conserved protein family found in eukaryotes that has been demonstrated to participate in the selection of integral membrane proteins as cargo for their correct targeting. Here it is demonstrated at the cellular level that rice cornichon OsCNIH1 interacts with OsHKT1;3 and, in yeast cells, enables the expression of the sodium transporter to the Golgi apparatus. Physical and functional HKT-cornichon interactions are confirmed by the mating-based split ubiquitin system, bimolecular fluorescence complementation, and Xenopus oocyte and yeast expression systems. The interaction between the two proteins occurs in the ER of plant cells and their co-expression in oocytes leads to the sequestration of the transporter in the ER. In the yeast cornichon mutant erv14, OsHKT1;3 is mistargeted, preventing the toxic effects of sodi...Continue Reading

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Citations

Oct 14, 2016·Frontiers in Plant Science·Concha DomingoManuel Talón
Apr 25, 2017·Plant, Cell & Environment·Juan PatishtanFrans J M Maathuis
Dec 28, 2019·Plants·Shahin ImranMaki Katsuhara
Oct 13, 2018·Journal of Experimental Botany·Julien BesnardSakiko Okumoto
Jun 7, 2020·Plant Molecular Biology·Xiaoshuang LiuJuan Li
Jun 15, 2019·Plant & Cell Physiology·Shan FuJixing Xia
Nov 27, 2019·International Journal of Molecular Sciences·Tianran ShiSakiko Okumoto
May 6, 2019·International Journal of Molecular Sciences·Antonella LocascioLynne Yenush
Oct 20, 2020·Trends in Plant Science·Daniel WipfPierre-Emmanuel Courty
Mar 7, 2021·International Journal of Molecular Sciences·Janin RiedelsbergerIngo Dreyer
Jul 10, 2017·Seminars in Cell & Developmental Biology·Federica Brandizzi
Sep 23, 2021·The Plant Cell·Fernando AnientoEugenia Russinova

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Methods Mentioned

BETA
PCR
fluorescence microscopy
fluorescence
GTPase

Software Mentioned

Image J
BiFC
ImageJ (
TMHMM
JACoP Plug - in

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