PMID: 2494323Jan 1, 1989Paper

Identification of rickettsiae in cutaneous biopsy specimens from dogs with experimental Rocky Mountain spotted fever

Journal of Veterinary Internal Medicine
M G DavidsonW E Sussman

Abstract

Direct immunofluorescence reaction for Rickettsia rickettsii was performed on formalin-fixed, paraffin-embedded cutaneous biopsy specimens collected from dogs with experimental Rocky Mountain spotted fever (RMSF). A technique of trypsin digestion of deparaffinized, rehydrated sections was successful in demonstrating discrete, immunofluorescent organisms in endothelia and adjacent vessel walls in the dermis. R rickettsii was identified only in grossly evident dermal lesions (macular rash or oral vesicles) and was not apparent in randomly collected biopsy specimens from clinically normal inguinal skin. These results suggest that clinical application of this technique for diagnosis of RMSF may be limited in dogs without cutaneous lesions.

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Citations

Mar 10, 2004·Journal of the American Animal Hospital Association·Edward B BreitschwerdtMichael D Willard
Jul 1, 1997·Veterinary Radiology & Ultrasound : the Official Journal of the American College of Veterinary Radiology and the International Veterinary Radiology Association·W T DrostM G Davidson
Mar 22, 2002·Pediatric Annals·Steven C Buckingham
May 8, 2013·Veterinary Clinical Pathology·Robin W Allison, Susan E Little
Nov 7, 2019·The Journal of Small Animal Practice·J SaastamoinenU Jeffery
Aug 12, 2017·Veterinary Ophthalmology·Nathaniel P Violette, Eric C Ledbetter

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