Abstract
This study aims to identify several RNA transcripts associated with the prognosis of kidney renal clear cell carcinoma (KIRC). The differentially expressed mRNAs, lncRNAs, and miRNAs (DEmRNAs, DElncRNAs, and DEmiRNAs) between KIRC cases and controls were screened based on an RNA-seq dataset from The Cancer Genome Atlas (TCGA) database. Subsequently, miRcode, miRDB, and TargetScan database were used to predict interactions between lncRNAs, miRNAs and target mRNAs. Then, a ceRNA network was built using miRNAs-mRNAs and lncRNAs-miRNAs pairs. Functional analysis of mRNAs in ceRNA was performed. Finally, the survival analysis of RNA transcripts in ceRNA network and correlation analysis for key RNA regulators were carried out. There were 1527 DElncRNAs, 54 DEmiRNAs, and 2321 DEmRNAs. A ceRNA network was constructed among 81 lncRNAs, 9 miRNAs, and 197 mRNAs. Functional analysis showed that numerous mRNAs were significantly associated with regulation of cellular glucuronidation. In addition, 35 lncRNAs, 84 mRNAs and two miRNAs were significantly corelated to the survival of patients with KIRC (P < 0.05). Among them, miRNA-21 and miRNA-155 were negatively related to three lncRNAs (LINC00472, SLC25A5.AS1, and TCL6). Seven mRNA targets of...Continue Reading
References
May 10, 2000·Nature Genetics·M AshburnerG Sherlock
Sep 5, 2002·Nature Reviews. Neuroscience·David F Owens, Arnold R Kriegstein
Dec 9, 2004·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Frede DonskovMarianne Hokland
Oct 21, 2005·Cancer Treatment Reviews·Beverly J Drucker
Oct 9, 2007·The Cancer Journal·Thomas E Hutson, Robert A Figlin
Mar 4, 2008·Cancer Treatment Reviews·Kiran GuptaClaudie Charbonneau
Aug 7, 2008·Cancer Letters·Daisuke MatsudaBin Tean Teh
Sep 8, 2009·Nucleic Acids Research·Lu Ping TanAnke van den Berg
Jun 26, 2010·Molecular Cancer·Henry ZallGeorg Häcker
Aug 2, 2011·Cell·Leonardo SalmenaPier Paolo Pandolfi
Feb 22, 2012·PloS One·Mohd Saif ZamanRajvir Dahiya
Mar 9, 2012·Urologia Internationalis·Takehiro SejimaAtsushi Takenaka
Mar 30, 2012·Omics : a Journal of Integrative Biology·Guangchuang YuQing-Yu He
Jun 22, 2012·Bioinformatics·Ashwini JeggariErik Larsson
Sep 28, 2013·Cancer Discovery·Florian A Karreth, Pier Paolo Pandolfi
Dec 7, 2013·Nucleic Acids Research·Sheng-Da HsuHsien-Da Huang
Jan 17, 2014·Nature·Yvonne TayPier Paolo Pandolfi
Dec 4, 2015·The Journal of Urology·Joanna BoguslawskaAgnieszka Piekielko-Witkowska
Dec 29, 2015·PLoS Genetics·Yunxia GeMing Yang
Mar 5, 2016·Cancer Cell International·Yongsheng ChenRuihua An
Jul 19, 2016·Urologic Oncology·Zsuzsanna SzabóGábor Halmos
Dec 3, 2016·Nucleic Acids Research·Minoru KanehisaKanae Morishima
Mar 10, 2017·Nature Reviews. Disease Primers·James J HsiehVincenzo Ficarra
Jun 24, 2017·Cell Death and Differentiation·Wei ZhaiChawnshang Chang
Nov 18, 2017·Journal of the American Society of Hypertension : JASH·Dominika KlimczakLeszek Pączek
Nov 18, 2017·Scientific Reports·Martin C S WongC F Ng
Dec 1, 2017·Neoplasia : an International Journal for Oncology Research·Tianhong PanRobert L Satcher
Jul 1, 2018·Critical Reviews in Oncology/hematology·Francesca De Felice, Vincenzo Tombolini
Aug 10, 2018·Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology·Peng LinGang Chen
Aug 30, 2018·Cell Death & Disease·Wei TianDajun Deng
Oct 3, 2018·Journal of Cellular Biochemistry·Jiawu WangXin Gou
Nov 9, 2018·Journal of Cancer·Li YuJianfeng Zhang
Nov 9, 2018·BioMed Research International·Kang YangJie Zhang
Dec 7, 2018·Molecular Carcinogenesis·Seema KhadirnaikarSudhanshu Kumar Shukla
Dec 12, 2018·Cancer Management and Research·Mingzhi XieYongqiang Li
Feb 23, 2019·Journal of Cellular and Molecular Medicine·Xiwen LiShaoqing Ju
May 8, 2019·Aging·Wenlong WangWeimin Fan
Jun 20, 2019·Frontiers in Oncology·Ei ShiomiWataru Obara
Aug 8, 2019·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Tianbo XuXiaoping Zhang
Sep 19, 2019·Journal of Cancer·Wen-Hao XuDing-Wei Ye
Oct 15, 2019·RNA Biology·Bo YeYan Guo