Identification of Schizosaccharomyces pombe in the guts of healthy individuals and patients with colorectal cancer: preliminary evidence from a gut microbiome secretome study

Gut Pathogens
Siok-Fong ChinHui-Min Neoh

Abstract

Over the years, genetic profiling of the gut microbiome of patients with colorectal cancer (CRC) using genome sequencing has suggested over-representation of several bacterial taxa. However, little is known about the protein or metabolite secretions from the microbiota that could lead to CRC pathology. Proteomic studies on the role of microbial secretome in CRC are relatively rare. Here, we report the identification of proteins from Schizosaccharomyces pombe found in the stool samples of both healthy individuals and patients with CRC. We found that distinctive sets of S. pombe proteins were present exclusively and in high intensities in each group. Our finding may trigger a new interest in the role of gut mycobiota in carcinogenesis.

References

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Nov 16, 2011·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Petra Langerak, Paul Russell
Jul 5, 2015·Applied Microbiology and Biotechnology·Mariana L PalmaBruno Douradinha
Jan 15, 2017·FEMS Yeast Research·Serge Gangloff, Benoit Arcangioli
May 16, 2018·Nucleic Acids Research·Jasmine ChongJianguo Xia

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Citations

Apr 24, 2020·Mediators of Inflammation·Voon Kin ChinMaha Abdullah
Dec 6, 2020·Biochimica Et Biophysica Acta. Reviews on Cancer·Xiali QinHailong Cao
Apr 4, 2021·Nutrients·Andreas Blesl, Vanessa Stadlbauer
Jul 3, 2021·Cancers·Natalia VallianouMaria Dalamaga

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Software Mentioned

Statistical Package for Social Sciences ( SPSS )
Database for Annotation , Visualisation and Integrated Discove...
MaxQuant
MetaboAnalyst

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