Identification of sequence selective receptors for peptides with a carboxylic acid terminus

Chemistry : a European Journal
Tobias M BraxmeierJeremy D Kilburn

Abstract

Split-and-mix libraries of resin-bound "tweezer" receptors have been prepared and screened to identify receptors for dye-labelled tripeptides. The receptors incorporate a diamidopyridine unit to serve as a specific recognition site for the CO2H group, leading to strong and selective receptors for peptide guests with a CO2H terminus. The role of the dye-label, attached to the peptide guest to allow visualisation of selective recognition events in the screening experiments, has also been examined and was found to have a significant influence on the binding selectivities.

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Citations

Jun 9, 2004·Current Opinion in Chemical Biology·Natarajan Srinivasan, Jeremy D Kilburn
Aug 29, 2006·Drug Discovery Today·Stephanie T WeissDavid J Merkler
Mar 29, 2002·Chemistry : a European Journal·Kim B JensenJeremy D Kilburn
Aug 23, 2016·Chemical Communications : Chem Comm·Thomas SchraderFrank-Gerrit Klärner
May 17, 2002·Angewandte Chemie·Mark Wehner, Thomas Schrader
Jun 3, 2004·Chembiochem : a European Journal of Chemical Biology·Yu LiuYoshihisa Inoue
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Aug 2, 2006·Chemistry : a European Journal·Thomas Suhs, Burkhard König
Jun 5, 2012·Dalton Transactions : an International Journal of Inorganic Chemistry·Toshiyuki MoriuchiToshikazu Hirao

Related Concepts

Polypeptides
Plasma Protein Binding Capacity
Substrate Specificity
Drug Modeling
Peptide Receptor
Molecular Mimicry
Synthetic Peptide Combinatorial Library
Combinatorial Chemistry Techniques

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