Identification of sequence variants and analysis of the role of the catechol-O-methyl-transferase gene in schizophrenia susceptibility

Biological Psychiatry
M KarayiorgouA E Pulver

Abstract

Deletions of 1.5-2 MB of chromosome 22q11 have been previously associated with schizophrenia. The deleted region includes proximally the region harboring genes involved in DiGeorge and velocardiofacial syndromes. Distally, it includes the gene for catechol-O-methyl-transferase (COMT), an enzyme that catalyzes the O-methylation of catecholamine neurotransmitters, including dopamine, and which therefore is considered a candidate gene for schizophrenia. We address the issue of a direct involvement of the COMT gene in the development of schizophrenia by employing the first extensive mutational analysis of this gene in a sample of 157 schizophrenia patients and 129 healthy controls, using single-strand conformation polymorphism and chemical cleavage methodologies. No mutations were found, but several sequence variants were identified, including the genetic polymorphism that underlies the high/low activity of the enzyme (a Val158-->Met change, which results in the creation of an NlaIII restriction site in the low-activity allele). The distribution of the NlaIII genotypes among subsets of schizophrenia patients was analyzed. The results presented here argue against a major role of COMT in schizophrenia in general (although a minor eff...Continue Reading

References

Jan 1, 1992·Journal of Psychiatric Research·P S WolyniecD Tam
Jan 1, 1989·Schizophrenia Bulletin·M F GreenF Kharabi
Dec 1, 1986·The American Journal of Psychiatry·T R Insel, H S Akiskal
Jan 1, 1983·Schizophrenia Bulletin·J D GuyM P Guy
Jan 1, 1984·The American Journal of Psychiatry·M BaronL Asnis
May 1, 1982·The American Journal of Psychiatry·C T GualtieriD Loiselle
Apr 24, 1995·American Journal of Medical Genetics·H P ValladaD Collier
Apr 24, 1995·American Journal of Medical Genetics·V K LasseterL Kasch
Aug 15, 1995·Proceedings of the National Academy of Sciences of the United States of America·P Propping, M M Nöthen
Aug 15, 1995·Proceedings of the National Academy of Sciences of the United States of America·M KarayiorgouV K Lasseter
Jan 1, 1995·Comprehensive Psychiatry·I BermanA I Green
Mar 15, 1994·American Journal of Medical Genetics·H CoonM Leppert
Apr 1, 1994·Acta Psychiatrica Scandinavica·G NestadtP R McHugh
Aug 1, 1994·The Journal of Nervous and Mental Disease·A E PulverD Housman
Jan 1, 1993·Schizophrenia Bulletin·J B Lohr, K Flynn
Oct 9, 1995·American Journal of Medical Genetics·S G SchwabM Ackenheil
Oct 9, 1995·American Journal of Medical Genetics·H W MoisesI I Gottesman
Jan 1, 1996·Genetic Epidemiology·K Y Liang, A E Pulver
Sep 1, 1981·Biochemical Pharmacology·Y FloderusL Wetterberg
Jun 12, 2013·Comprehensive Psychiatry·Albina R TorresLeonardo F Fontenelle

❮ Previous
Next ❯

Citations

May 17, 2000·American Journal of Medical Genetics·A S BassettR Weksberg
Dec 17, 2008·Neurotoxicity Research·Willem M A Verhoeven, Siegfried Tuinier
Jul 18, 2002·Annales de génétique·A VogelsJ P Frijns
Aug 10, 2002·Journal of Psychosomatic Research·Perminder Sachdev
Nov 30, 2005·Molecular Psychiatry·K FujiiA Sawa
Apr 23, 2005·Child Neuropsychology : a Journal on Normal and Abnormal Development in Childhood and Adolescence·Carrie E BeardenTony J Simon
Apr 7, 2007·Schizophrenia Bulletin·Hywel J WilliamsMichael C O'Donovan
Jun 20, 2008·Schizophrenia Bulletin·Haraldur Magnus HaraldssonHannes Petursson
Mar 20, 2003·Genetics in Medicine : Official Journal of the American College of Medical Genetics·Taichi KatoRumiko Matsuoka
Jun 8, 2002·Annual Review of Neuroscience·W Maxwell CowanSteven E Hyman
Aug 27, 2009·Biologics : Targets & Therapy·Willem Ma VerhoevenIneke van der Burgt
Aug 3, 2013·Molecular Neurobiology·Hongjuan SunJing Wu
Aug 26, 1998·Proceedings of the National Academy of Sciences of the United States of America·J A GogosM Karayiorgou
Jun 8, 2001·Proceedings of the National Academy of Sciences of the United States of America·M F EganD R Weinberger
May 6, 2003·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Ari IlliEsa Leinonen
Feb 9, 2016·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·Ryoko HigashiyamaHeii Arai
Oct 30, 2015·Progress in Neurobiology·Yavuz AyhanMikhail V Pletnikov
Mar 31, 2009·Schizophrenia Research·Tomo OkochiNakao Iwata
Feb 22, 2000·Biological Psychiatry·A E Pulver
Aug 25, 2005·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·Elena MichaelovskyAbraham Weizman
Jan 12, 2010·Biological Psychiatry·Philipp G SandStefan Smesny
Mar 19, 2014·Frontiers in Behavioral Neuroscience·Sean C Godar, Marco Bortolato
Oct 11, 2002·Mayo Clinic Proceedings·Janet L SobellCynthia T McMurray
May 22, 2010·Journal of Psychiatric Research·Javier CostasManuel Arrojo
Jul 28, 2016·The World Journal of Biological Psychiatry : the Official Journal of the World Federation of Societies of Biological Psychiatry·Marco BortolatoJackob Moskovitz
Oct 29, 2003·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·George S ZubenkoMary L Marazita
Sep 2, 2004·Molecular Psychiatry·A R SandersP V Gejman
Jul 13, 2002·American Journal of Medical Genetics·Nadine NortonMichael J Owen
May 30, 2001·American Journal of Medical Genetics·P D ArnoldR Schachar
Dec 3, 1999·American Journal of Medical Genetics·C L BarrJ L Kennedy
Aug 22, 2006·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·J L McClayX Chen

❮ Previous
Next ❯

Related Concepts

Related Feeds

22q11 Deletion Syndrome

22q11.2 deletion syndrome, also known as DiGeorge syndrome, is a congenital disorder caused by a partial deletion of chromosome 22. Symptoms include heart defects, poor immune system function, a cleft palate, complications related to low levels of calcium in the blood, and delayed development. Discover the latest research on this disease here.

Related Papers

European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology
Tae-Won ParkDaehee Kang
American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics
Toshiya InadaYoshimi Iijima
© 2022 Meta ULC. All rights reserved