May 23, 1986

Identification of sequences in a yeast histone promoter involved in periodic transcription

Cell
M A OsleyL Hereford

Abstract

Sequences between a pair of divergently transcribed histone genes in Saccharomyces cerevisiae are able to confer periodic transcription during the cell cycle. This conclusion contrasts to our previous hypothesis that an ars (autonomously replicating sequence) 3' to this locus is a transcription timer for yeast histone genes. The promoter sequences required for periodic expression have been localized by deletion analysis, and isolated elements have been analyzed by insertion into a heterologous promoter. Two cell-cycle-specific promoter functions have been identified. One function activates transcription in a cell-cycle-dependent manner. The other periodically represses transcription. Negative regulation may be the predominant form of cell-cycle control, because removal of the repressing function results in constitutive expression of the histone genes.

Mentioned in this Paper

Histone antigen
Saccharomyces cerevisiae allergenic extract
Transcription, Genetic
Gene Deletion Abnormality
Promoter
Partial Monosomy
Replicon
Genes, Fungal
Deletion Mutation
Cell Cycle

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