Identification of significant geographic clustering of polycythemia vera cases in Montreal, Canada

Cancer
Michelle LeIvan V Litvinov

Abstract

Polycythemia vera (PV) is a chronic myeloproliferative neoplasm associated at times with debilitating symptoms and a significant mortality rate. Understanding the demographics, epidemiology, and geography of this disease may provide further insight into important risk factors associated with its development. The objective of this study was to analyze patient demographics, incidence, and mortality rates, as well as the geographic distribution of PV patients in Canada between 1992 and 2010. This study was achieved by analyzing the Canadian Cancer Registry, Le Registre Québécois du Cancer, and the Canadian Vital Statistics patient databases. A total of 4645 patients were diagnosed with PV between 1992 and 2010. While the annual incidence rate of this cancer fluctuated in Canada, mortality rate analysis indicated a decreasing trend. Geographically, PV incidence rates were notably elevated in the province of Quebec compared with the Canadian average. Further analysis of high-incidence forward sortation areas indicated a striking clustering of cases in the H4W region encompassing the Côte-Saint-Luc borough of Montreal, with an incidence of 102.97 (95% confidence interval, 75.11-137.79) cases per million per year, which is >13 times t...Continue Reading

References

Feb 17, 2001·International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases·F K Käferstein
Jan 1, 1995·Biographical Memoirs of Fellows of the Royal Society·H Imura
Feb 14, 2003·Mayo Clinic Proceedings·Ayalew Tefferi
Apr 1, 1955·Journal of Chronic Diseases·M M WINTROBE
Apr 29, 2005·The New England Journal of Medicine·Robert KralovicsRadek C Skoda
Jan 9, 2008·American Journal of Hematology·Xiaomei MaH Andrew Selinger
Feb 5, 2009·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Vincent SeamanRonald Hoffman
Jul 10, 2010·International Journal of Environmental Research and Public Health·Vincent SeamanHenry Cole
Sep 2, 2015·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Brady L SteinRonald Hoffman
May 28, 2017·The Journal of Experimental Medicine·Christelle FreitasKarl Balabanian
Dec 16, 2017·Journal of Cutaneous Medicine and Surgery·Feras M GhazawiIvan V Litvinov
Aug 10, 2018·Journal of the American Academy of Dermatology·Feras M GhazawiIvan V Litvinov
Oct 17, 2018·Journal of Cutaneous Medicine and Surgery·Feras M Ghazawi, Ivan V Litvinov
Nov 6, 2018·Journal of the American Academy of Dermatology·Feras M GhazawiIvan V Litvinov
Mar 12, 2019·Current Oncology·L AmarI V Litvinov
Mar 20, 2019·Journal of Pediatric Ophthalmology and Strabismus·Rami DarwichIvan V Litvinov

❮ Previous
Next ❯

Citations

Dec 25, 2019·Cancer·Feras M GhazawiIvan V Litvinov
Nov 15, 2019·Journal of Cutaneous Medicine and Surgery·François LagacéIvan V Litvinov
Apr 3, 2020·Journal of Cutaneous Medicine and Surgery·Feras M GhazawiIvan V Litvinov
Nov 15, 2019·The British Journal of Ophthalmology·Rami DarwichIvan V Litvinov
Jan 18, 2020·The British Journal of Ophthalmology·Rami DarwichIvan V Litvinov
Feb 23, 2021·Current Oncology·François LagacéIvan V Litvinov
Apr 18, 2021·HPB : the Official Journal of the International Hepato Pancreato Biliary Association·Yasi XiaoIvan V Litvinov
Jun 3, 2021·Current Oncology·Leila CattelanElena Netchiporouk

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.