Identification of single nucleotide polymorphisms in the human kallikrein 10 (KLK10) gene and their association with prostate, breast, testicular, and ovarian cancers

The Prostate
Bhupinder B BharajEleftherios P Diamandis

Abstract

The KLK10 gene (also known as the normal epithelial cell-specific 1 gene) is a member of the expanded human kallikrein gene family. Recently, it has been reported that KLK10 is a tumor suppressor gene and that its expression is downregulated in various forms of cancer and cancer cell lines. KLK10 is also upregulated in ovarian cancer. We thus hypothesized that the KLK10 gene may be a target for mutations in various cancers. We sequenced the five coding exons of the KLK10 gene using genomic DNA from various tumors, normal tissues, and blood, by PCR amplification and automated sequencing. In none of the tumor-derived DNAs, we identified somatic mutations that could inactivate this gene. However, we identified a prevalent germline single nucleotide variation at codon 50 (exon 3) of this gene [GCC (alanine) to TCC (serine)]. The GCC genotype was less prevalent in prostatic cancer patients in comparison to control subjects (P = 0.027) but no differences were seen with testicular, ovarian, and breast cancer. We also identified four genetic variations in exon 4, at codons106 [GGC (glycine) to GGA (glycine)], codon 112 [ACG (threonine) to ACC (threonine)], codon 141 [CTA (leucine) to CTG (leucine)], and at codon 149 [CCG (proline) to C...Continue Reading

References

May 1, 1992·Clinical & Experimental Metastasis·M J Duffy
Jan 1, 1985·Advances in Cancer Research·K DanøL Skriver
Feb 16, 1994·Journal of the National Cancer Institute·R K Ross, B E Henderson
Feb 15, 1993·Cancer·S AznavoorianL A Liotta
Jan 1, 1996·Journal of Clinical Laboratory Analysis·E P Diamandis, H Yu
Jul 2, 1998·Biochemical and Biophysical Research Communications·L LuoE P Diamandis
Oct 26, 1999·Current Biology : CB·L M Matrisian
Jan 5, 2000·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·S SunyaevP Bork
Mar 1, 2000·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·A R NelsonL M Matrisian
Nov 9, 2000·American Journal of Human Genetics·E A Ostrander, J L Stanford
Feb 13, 2001·Current Biology : CB·L J McCawley, L M Matrisian
Feb 15, 2001·Nature Genetics·M E Peters, E A Ostrander
Mar 15, 2001·Proceedings of the National Academy of Sciences of the United States of America·E Levy-LahadR Gershoni-Baruch
Mar 29, 2001·The Journal of Molecular Diagnostics : JMD·M R Emmert-BuckR H Waterston
Apr 3, 2001·Clinica Chimica Acta; International Journal of Clinical Chemistry·L Y LuoE P Diamandis
May 1, 2001·Nature Medicine·K L NathansonK N Nathanson
Oct 2, 2001·CA: a Cancer Journal for Clinicians·R T GreenleeM Thun

❮ Previous
Next ❯

Citations

Dec 3, 2009·Mammalian Genome : Official Journal of the International Mammalian Genome Society·Katerina Angelopoulou, George S Karagiannis
Mar 28, 2003·Genomics·Catherine I DumurAndrea Ferreira-Gonzalez
Nov 2, 2004·Nature Reviews. Cancer·Carla A Borgoño, Eleftherios P Diamandis
Aug 25, 2006·Journal of Gastroenterology and Hepatology·Bo FengZheng-Gang Zhu
Jun 28, 2006·Biological Chemistry·Ying ZhangVimla Band
Feb 12, 2010·Future Oncology·Konstantinos Mavridis, Andreas Scorilas
May 25, 2005·Cancer Letters·Christina V Obiezu, Eleftherios P Diamandis
Aug 6, 2010·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Jyotsna BatraAmanda B Spurdle
Oct 29, 2005·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Michael SidiropoulosEleftherios P Diamandis
Apr 17, 2012·Biological Chemistry·Maria D PasicGeorge M Yousef
Apr 30, 2005·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·V Griol-CharhbiliC Richer
Sep 10, 2016·Biological Chemistry·Mekdes DebelaPeter Goettig
Sep 28, 2004·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Jianghua WangMichael Ittmann
Apr 23, 2004·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Jennifer ListgartenBrent Zanke

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Clinica Chimica Acta; International Journal of Clinical Chemistry
L-Y LuoEleftherios P Diamandis
Gynecologic Oncology
Hyun S ShvartsmanRosemarie Schmandt
© 2022 Meta ULC. All rights reserved