Identification of small clusters of divergent amino acids that mediate the opposing effects of ras and Krev-1

Science
K ZhangD R Lowy

Abstract

Krev-1 is an anti-oncogene that was originally identified by its ability to induce morphologic reversion of ras-transformed cells that continue to express the ras gene. The Krev-1-encoded protein is structurally related to Ras proteins. The biological activities of a series of ras-Krev-1 chimeras were studied to test the hypothesis that Krev-1 may directly interfere with a ras function. The ras-specific and Krev-1-specific amino acids immediately surrounding residues 32 to 44, which are identical between the two proteins, determined whether the protein induced cellular transformation or suppressed ras transformation. Because this region in Ras proteins has been implicated in effector function, the results suggest that Krev-1 suppresses ras-induced transformation by interfering with interaction of Ras with its effector.

References

Dec 1, 1977·Proceedings of the National Academy of Sciences of the United States of America·F SangerA R Coulson
Jun 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·H KitayamaM Noda
Jul 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·I S SigalE M Scolnick
Jun 1, 1989·Microbiological Reviews·J B Gibbs, M S Marshall
Feb 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·D G LoweD V Goeddel
Jan 1, 1987·Annual Review of Biochemistry·M Barbacid
Dec 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·N TouchotA Tavitian
Jan 16, 1987·Science·J M Bishop
May 1, 1985·Cell·P Madaule, R Axel

❮ Previous
Next ❯

Citations

Sep 1, 1991·Journal of Cellular Physiology·K ReissR Baserga
Mar 1, 1994·Molecular and Biochemical Parasitology·P S ShenJ Samuelson
Mar 1, 1994·Cellular Signalling·L Wiesmüller, F Wittinghofer
Jan 1, 1996·Progress in Biophysics and Molecular Biology·C Herrmann, N Nassar
Aug 1, 1996·Nature Structural Biology·F McCormick
Aug 1, 1996·Nature Structural Biology·N NassarA Wittinghofer
Jul 27, 2000·Molecular and Cellular Biology·Y OhbaM Matsuda
Jun 1, 1991·Environmental Health Perspectives·H KitayamaM Noda
Jul 14, 2010·Future Oncology·Makoto NodaHitoshi Kitayama
Apr 18, 2002·Proceedings of the National Academy of Sciences of the United States of America·Fernando Ribeiro-NetoDaniel L Altschuler
Jun 24, 1998·Proceedings of the National Academy of Sciences of the United States of America·D L Altschuler, F Ribeiro-Neto
Jul 17, 1995·FEBS Letters·D P MolloyR J Grand
Jan 1, 1992·Molecular Carcinogenesis·J CaamanoA J Klein-Szanto
Jan 25, 1991·Cell·L C CantleyS Soltoff
Sep 1, 1993·Trends in Endocrinology and Metabolism : TEM·D Wynford-Thomas
Oct 29, 2002·Nature Cell Biology·Jorrit M EnserinkJohannes L Bos
Jan 27, 1999·Biochimica Et Biophysica Acta·D J Gawler
Oct 2, 2007·Journal of Stroke and Cerebrovascular Diseases : the Official Journal of National Stroke Association·Sepideh Amin Hanjani
Jan 1, 1996·Molecular Carcinogenesis·S StangJ C Stone
Jun 1, 1994·Current Biology : CB·T Schweins, A Wittinghofer
Mar 3, 1995·The Journal of Biological Chemistry·J Fujita-YoshigakiS Yokoyama
Aug 28, 2004·The Journal of Biological Chemistry·Fernando Ribeiro-NetoDaniel L Altschuler
Aug 25, 1995·The Journal of Biological Chemistry·C H KwongT L Leto
Apr 18, 1997·The Journal of Biological Chemistry·G J ClarkC J Der

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.