Identification of Soluble Mediators in IgG-Mediated Anaphylaxis via Fcγ Receptor: A Meta-Analysis

Frontiers in Immunology
Audrey Siew Foong KowChau Ling Tham

Abstract

Background: Anaphylaxis is an acute and life-threatening allergic response. Classically and most commonly, it can be mediated by the crosslinking of allergens to immunoglobulin E (IgE)- high affinity IgE receptor (FcεRI) complex found mostly on mast cells. However, there is another pathway of anaphylaxis that is less well-studied. This pathway known as the alternative pathway is mediated by IgG and its Fc gamma receptor (Fcγ). Though it was not documented in human anaphylaxis, a few studies have found that IgG-mediated anaphylaxis can happen as demonstrated in rodent models of anaphylaxis. In these studies, a variety of soluble mediators were being evaluated and they differ from each study which causes confusion in the suitability, and reliability of choice of soluble mediators to be analyzed for diagnosis or therapeutic purposes. Hence, the objective of this meta-analysis is to identify the potential soluble mediators that are involved in an IgG-mediated anaphylaxis reaction. Methods: Studies related to IgG-mediated anaphylaxis were sourced from five search engines namely PubMed, Scopus, Ovid, Cochrane Library, and Center for Agricultural Bioscience International (CABI) regardless of publication year. Relevant studies were the...Continue Reading

References

Jan 1, 1983·International Archives of Allergy and Applied Immunology·M EnnisC T Dollery
Aug 4, 1994·Nature·H C OettgenP Leder
Nov 20, 1998·Clinical and Experimental Immunology·H WakayamaK Shimokata
Mar 26, 2002·Immunity·Muriel LaffargueMatthias P Wymann
Apr 10, 2002·The Journal of Allergy and Clinical Immunology·Richard T StraitFred D Finkelman
Sep 10, 2002·Molecular Immunology·Christine TkaczykDean D Metcalfe
Mar 21, 2003·The Journal of Immunology : Official Journal of the American Association of Immunologists·Richard T StraitFred D Finkelman
Mar 27, 2003·British Dental Journal·J M Scholey, J E Harrison
Jul 2, 2003·The Journal of Experimental Medicine·Il-Whan ChoiHern-Ku Lee
Sep 4, 2007·The Journal of Allergy and Clinical Immunology·Fred D Finkelman
Jan 4, 2008·The New England Journal of Medicine·Peter VadasJupiter Yeung
Jul 4, 2008·Current Opinion in Allergy and Clinical Immunology·Richard D Peavy, Dean D Metcalfe
Jul 16, 2008·International Archives of Allergy and Immunology·Nam-In KangHern-Ku Lee
Sep 22, 2009·The Journal of Allergy and Clinical Immunology·Shelley F StoneUNKNOWN Emergency Department Anaphylaxis Investigators
Jun 22, 2010·Allergy·M Ben-Shoshan, A E Clarke
Dec 8, 2010·Critical Reviews in Eukaryotic Gene Expression·Narayanan Parameswaran, Sonika Patial
Jun 11, 2011·Current Opinion in Allergy and Clinical Immunology·Bilal Q Khan, Stephen F Kemp
Jul 5, 2011·The Journal of Orthopaedic and Sports Physical Therapy·Heidi Israel, Randy R Richter
Jul 13, 2011·Proceedings of the National Academy of Sciences of the United States of America·Marat V KhodounFred D Finkelman
Sep 24, 2011·International Journal of Rheumatology·Theresa C BarnesRobert J Moots
Nov 17, 2011·Current Allergy and Asthma Reports·Shelley F Stone, Simon G A Brown
Mar 28, 2012·The Journal of Immunology : Official Journal of the American Association of Immunologists·Yves T FalangaJohn J Ryan
Jul 13, 2014·The Journal of Immunology : Official Journal of the American Association of Immunologists·Nobuyuki FukuishiMasaaki Akagi
Jun 9, 2015·The Journal of Allergy and Clinical Immunology·Parwinder GillPeter Vadas
Jul 21, 2015·Cytokine & Growth Factor Reviews·Fred Schaper, Stefan Rose-John
May 1, 2016·The Journal of Allergy and Clinical Immunology·Fred D FinkelmanRichard Strait
May 11, 2016·Journal of Investigational Allergology & Clinical Immunology·R Muñoz-CanoJ Bartra
Jun 2, 2016·The Journal of Allergy and Clinical Immunology·Héloïse BeutierFriederike Jönsson
Jun 25, 2016·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Lufen HuangLiang Liu
Jun 15, 2017·Frontiers in Immunology·Maria Isabel MontañezInmaculada Doña
Aug 7, 2017·The Journal of Allergy and Clinical Immunology·Laurent L ReberStephen J Galli
Oct 12, 2017·Frontiers in Immunology·Rosa Muñoz-CanoJoan Bartra
Apr 15, 2018·Science Immunology·Héloïse BeutierFriederike Jönsson

❮ Previous
Next ❯

Citations

Oct 11, 2019·International Journal of Molecular Sciences·Misun KimDooil Jeoung
May 7, 2020·International Journal of Molecular Sciences·Yining JinVenugopal Gangur
Jan 26, 2021·Journal of Immunological Methods·Anne-Emmanuelle BergerClaude Lambert
Aug 8, 2021·International Journal of Molecular Sciences·Samantha Minh Thy NguyenGuha Krishnaswamy

❮ Previous
Next ❯

Software Mentioned

Excel Worksheet Window
Scopus
Ovid
Get Data Graph Digitiser
ImageJ
Meta
OpenMeta [ Analyst

Related Concepts

Related Feeds

Anaphylaxis

Anaphylaxis is a serious allergic reaction that is rapid in onset and may cause death.