Identification of spore allergens from the indoor mould Aspergillus versicolor

Allergy
D BenndorfM von Bergen

Abstract

Indoor mould growth and dampness are associated with respiratory health effects and allergies and several studies demonstrated that mainly Aspergillus versicolor and Penicillium expansum are responsible for indoor mould exposure. In contrast, commercialized test systems to diagnose allergic reactions to this mould species are not available. In this study, allergenic proteins from spores of the indoor relevant species A. versicolor and P. expansum should get detected and identified. We used two-dimensional (2D)-gel electrophoresis of spore proteins and immunoblotting with sera from patients participating in an epidemiologic study about indoor exposure of moulds and their influence on the development of allergies (ESTERSPEGA). Sera were screened for IgE antibodies specific for proteins from A. versicolor, A. fumigatus and P. expansum in one-dimensional blots and in 2D immunoblots. From the 2D gels, the corresponding spots were picked and identified by mass spectrometry. More than 20 allergens from A. versicolor were identified; in particular, seven major allergens were selected, which were detected by more than 90% of the positive sera. The most abundant allergen was glyceraldehyde-3-phosphate dehydrogenase, followed by an unname...Continue Reading

References

Mar 1, 1980·Applied and Environmental Microbiology·A D Hocking, J I Pitt
Apr 1, 1993·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·R B SporikT A Platts-Mills
Dec 10, 1996·Proceedings of the National Academy of Sciences of the United States of America·A ShevchenkoM Mann
Jul 29, 1999·Environmental Health Perspectives·U HaverinenA Nevalainen
Mar 28, 2002·Applied and Environmental Microbiology·Brian G SheltonGeorge K Morris
Jul 10, 2002·Chemical Immunology·Michael Breitenbach, Birgit Simon-Nobbe
Aug 24, 2002·BMJ : British Medical Journal·Mahmoud ZureikUNKNOWN European Community Respiratory Health Survey
Jun 5, 2003·Fungal Genetics and Biology : FG & B·Kristian Fog Nielsen
Aug 9, 2003·Current Allergy and Asthma Reports·Viswanath P Kurup
Mar 6, 2004·Mycological Research·Olf HerbarthMatthias Richter
Aug 30, 2005·International Archives of Allergy and Immunology·Adriano Mari
Oct 8, 2005·Expert Review of Proteomics·Hélène Chardin, Gabriel Peltre
Nov 29, 2007·The ISME Journal·Dirk BenndorfMartin von Bergen
Sep 1, 2006·Medical Mycology·P BowyerD W Denning

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Citations

Jun 30, 2009·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·Nichole A ReisdorphCarolyn Broccardo
Dec 29, 2011·Arhiv za higijenu rada i toksikologiju·Ljerka Prester
Jan 21, 2014·Journal of Proteome Research·Nitat SookrungWanpen Chaicumpa
Jul 1, 2010·Arhiv za higijenu rada i toksikologiju·Ljerka PresterMarija Vucemilo
May 16, 2013·Environmental Science. Processes & Impacts·Eva ZahradnikMonika Raulf-Heimsoth
Jun 29, 2013·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·Ajay P NayakDonald H Beezhold
Jun 1, 2011·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·Orathai JirapongsananurukSurapon Piboonpocanun
Mar 9, 2010·Revue des maladies respiratoires·G RebouxL Millon
Jun 26, 2008·Journal of Microbiological Methods·Silke MatysikAndrea Mueller
Dec 17, 2008·Cytometry. Part a : the Journal of the International Society for Analytical Cytology·Franziska HeineSusann Müller
Oct 25, 2013·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·S KespohlM Raulf-Heimsoth
Jun 22, 2013·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·G WeinmayrUNKNOWN ISAAC Phase Two Study Group
Mar 24, 2016·Biochimica Et Biophysica Acta·Debarati DeySwati Gupta Bhattacharya
Jul 6, 2014·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·Suparada KhanaruksombatPharima Phiriyangkul
Aug 23, 2011·The Journal of Allergy and Clinical Immunology·Keity Souza SantosFabio Fernandes Morato Castro
Nov 30, 2010·Molecular Immunology·Michelle L van der VentelAndreas L Lopata
Aug 21, 2013·Saudi Journal of Biological Sciences·A A Haleem Khan, S Mohan Karuppayil
Nov 22, 2013·Environmental Science. Processes & Impacts·William R RittenourBrett J Green
Dec 17, 2014·Monoclonal Antibodies in Immunodiagnosis and Immunotherapy·Brett J GreenDonald H Beezhold
May 28, 2016·Current Environmental Health Reports·Lidia CasasMartin Täubel
Mar 31, 2016·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·S KespohlM Raulf
Jun 18, 2016·Proteomics. Clinical Applications·Olaf KniemeyerAxel A Brakhage
Apr 6, 2017·International Archives of Allergy and Immunology·Frances Vilá-HéreterBenjamín Bolaños-Rosero
Aug 5, 2017·Materials·Madson R E SantosJorge F J Coelho
Jun 21, 2015·Applied and Environmental Microbiology·Komlavi Anani AfanouBrett James Green
Mar 29, 2019·International Journal of Environmental Research and Public Health·Elisabeth ØyaJørn A Holme
May 23, 2019·Journal of Toxicology and Environmental Health. Part a·Elisabeth ØyaJørn A Holme
Feb 23, 2020·Indoor Air·Jørn A HolmeWijnand Eduard
May 3, 2019·International Journal of Environmental Health Research·Debarati Dey, Swati Gupta Bhattacharya
Apr 16, 2011·Journal of Environmental Monitoring : JEM·Manuela OliveiraIlda Abreu
Jul 6, 2017·International Journal of Environmental Research and Public Health·Mary Augustina EgbutaOlubukola Oluranti Babalola

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Aspergillosis (ASM)

Aspergillosis is the name given to a wide variety of diseases caused by infection by fungi of the genus Aspergillus. Aspergillosis occurs in chronic or acute forms which are clinically very distinct. Most cases of acute aspergillosis occur in patients with severely compromised immune systems. Chronic colonization or infection can cause complications in people with underlying respiratory illnesses. Discover the latest research on aspergillosis here.

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Aspergillosis is the name given to a wide variety of diseases caused by infection by fungi of the genus Aspergillus. Aspergillosis occurs in chronic or acute forms which are clinically very distinct. Most cases of acute aspergillosis occur in patients with severely compromised immune systems. Chronic colonization or infection can cause complications in people with underlying respiratory illnesses. Discover the latest research on aspergillosis here.

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