Identification of subjects at risk for colorectal carcinoma through a test based on K-ras determination in the stool

Gastroenterology
E VillaF Manenti

Abstract

The gold standard for screening for colorectal carcinoma is colonoscopy. The aim of this study was to compare endoscopic results with those obtained using the noninvasive screening test of K-ras determination in the stool in a large population of patients undergoing colonoscopy. Two hundred thirty consecutive patients were studied by K-ras amplification on stool-derived DNA using polymerase chain reaction and oligomer-specific hybridization. Wild-type K-ras was amplified in 103 of 230 patients (44.8%), the rate of amplification being directly proportional to the presence of an organic disease of the intestine characterized by hyperproliferating mucosa. In 30 of these 103 patients (29.1%), a K-ras mutation was found. Four of 5 with early colorectal carcinoma, all who had K-ras mutations in the tumor, were identified. In first-degree relatives of patients with colorectal carcinoma, all subjects either carrying adenomas > 1 cm in diameter or multiple smaller adenomas were identified. In patients with inflammatory bowel disease, the test identified the only patient with neoplastic transformation. The sensitivity and specificity of K-ras determination on stool-derived DNA in patients with colorectal carcinoma, in first-degree relati...Continue Reading

Citations

Jul 14, 2012·International Journal of Colorectal Disease·Giles O ElliottNigel J Belshaw
Feb 1, 2002·The New England Journal of Medicine·Giovanni TraversoBert Vogelstein
Aug 25, 2001·The British Journal of Nutrition·F BrancaH Verhagen
Jun 8, 2001·Journal of the National Cancer Institute·W Atkin, J P Martin
Mar 26, 2009·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Ching Hang WongMark M Moasser
Oct 30, 2004·Scandinavian Journal of Gastroenterology·E M M Van LieshoutR Van der Meer
Jan 10, 2003·Biomarkers : Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals·Laurie A DavidsonRobert S Chapkin
Nov 19, 2004·Neoplasia : an International Journal for Oncology Research·Daniele CalistriDino Amadori
May 10, 2005·International Journal of Cancer. Journal International Du Cancer·Ulrike Haug, Hermann Brenner
Jun 12, 2004·Alimentary Pharmacology & Therapeutics·K S TagoreM J Lawson
Nov 14, 2008·NMR in Biomedicine·Daniel MonleónBernardo Celda
Mar 14, 2007·International Journal of Cancer. Journal International Du Cancer·Alexandre Loktionov
Jul 10, 2009·International Journal of Cancer. Journal International Du Cancer·Alexandre LoktionovNeil J Mortensen
Feb 24, 2005·Seminars in Oncology·Matthew Q Bromer, David S Weinberg
Jun 22, 2001·Experimental and Molecular Pathology·B R DoolittleJ Costa
Apr 24, 2002·Best Practice & Research. Clinical Gastroenterology·Jean FaivreClaire Bonithon-Kopp
Feb 29, 2016·Journal of Gastrointestinal Cancer·Andrea IannoneAlfredo Di Leo
Apr 30, 2002·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·J Walker, P Quirke
Nov 26, 2003·The American Journal of Gastroenterology·Masakatsu MizunoYasushi Shiratori
Dec 18, 2001·Seminars in Surgical Oncology·P Kienle, M Koch
Nov 23, 2000·Journal of Surgical Oncology·S Ottó, S Eckhardt
Jun 22, 2002·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·Tatiana BandaletovaAlexandre Loktionov
Apr 23, 2002·Journal of Surgical Oncology·Minori KoshijiKazuhiko Yoshioka
Dec 1, 1996·The Journal of Pathology·J W Arends, F T Bosman
Feb 4, 2016·Arquivos De Gastroenterologia·Yolanda TeixeiraNora Manoukian Forones
Aug 18, 2005·Diagnostic Molecular Pathology : the American Journal of Surgical Pathology, Part B·Jeff OlsonAnthony P Shuber
Apr 29, 1998·Journal of the National Cancer Institute·M A PotterA H Wyllie
Jun 3, 2006·Diseases of the Colon and Rectum·Michael R ThompsonW S Atkin
Aug 22, 2007·Annals of Surgical Oncology·David Z J ChuYun Yen
Apr 11, 2006·Annals of Surgical Oncology·Steve R MartinezAnton J Bilchik
Aug 4, 2006·Molecular Diagnosis & Therapy·Sudhir Srivastava
Jun 21, 2003·Clinical Chemistry·Corné H W KlaassenFrederik B J M Thunnissen
Oct 4, 2002·European Journal of Gastroenterology & Hepatology·Maria HeinzlmannKlaus Loeschke
Apr 13, 2000·Journal of Cellular Biochemistry. Supplement·Z LevA Lerner
May 7, 2003·Der Internist·C PoxW Schmiegel
May 2, 2003·Annals of the New York Academy of Sciences·Adrian M JubbAdam J Oates
Apr 1, 1997·Journal of Clinical Gastroenterology·C R Kapadia
Sep 5, 2006·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Bernard Levin
Dec 9, 1998·The American Journal of Physiology·C SpirlìM Strazzabosco
Jul 1, 2004·The British Journal of Surgery·T MakJ Hill
Dec 1, 2001·Clinica Chimica Acta; International Journal of Clinical Chemistry·David A Ahlquist, Anthony P Shuber
Dec 12, 2001·Critical Reviews in Oncology/hematology·T Minamoto, Z Ronai

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Gastroentérologie Clinique Et Biologique
P StrockA Kerschen
Arquivos De Gastroenterologia
João Carlos Andreoli, René Lambert
© 2021 Meta ULC. All rights reserved