Identification of survival‑associated key genes and long non‑coding RNAs in glioblastoma multiforme by weighted gene co‑expression network analysis

International Journal of Molecular Medicine
Xin ChenLiwei Zhang

Abstract

Glioblastoma multiforme (GBM) is the most common and aggressive primary malignant brain tumour. However, the causes of GBM are not clear, and the prognosis remains poor. The aim of the present study was to elucidate the key coding genes and long non‑coding RNAs (lncRNAs) associated with the survival time of GBM patients by obtaining the RNA expression profiles from the Chinese Glioma Genome Atlas database and conducting weighted gene co‑expression network analysis. Modules associated with overall survival (OS) were identified, and Gene Ontology and pathway enrichment analyses were performed. The hub genes of these modules were validated via survival analysis, while the biological functions of crucial lncRNAs were also analysed in the publicly available data. The results identified a survival‑associated module with 195 key genes. Among them, 33 key genes were demonstrated to be associated with OS, and the majority of these were involved in extracellular matrix‑associated and tyrosine kinase receptor signalling pathways. Furthermore, LOC541471 was identified as an OS‑associated lncRNA, and was reported to be involved in the oxidative phosphorylation of GBM with pleckstrin‑2. These findings may significantly enhance our understand...Continue Reading

References

Sep 24, 2002·Journal of Cell Science·Roumen Pankov, Kenneth M Yamada
Feb 21, 2003·Glia·Lýdia VargováEva Syková
Mar 11, 2005·The New England Journal of Medicine·Roger StuppUNKNOWN National Cancer Institute of Canada Clinical Trials Group
Jan 30, 2007·Cellular and Molecular Life Sciences : CMLS·M NakadaM E Berens
Dec 31, 2008·BMC Bioinformatics·Peter Langfelder, Steve Horvath
Jan 12, 2010·Journal of Neuro-oncology·Yang LiuKevin A Walter
May 4, 2010·Nature Biotechnology·Cory Y McLeanGill Bejerano
Jul 22, 2010·Molecular Cancer·Svetlana A MikheevaRobert C Rostomily
Mar 2, 2012·Glia·Nikki A CharlesHelmut Kettenmann
Apr 5, 2012·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Michael DeLayManish K Aghi
Aug 11, 2012·Advances in Experimental Medicine and Biology·Aneta Kwiatkowska, Marc Symons
Aug 18, 2012·Genes & Development·Michalina JaniszewskaIvan Stamenkovic
Oct 15, 2013·Cell·Cameron W BrennanUNKNOWN TCGA Research Network
Jan 22, 2014·Glia·René Günther FeichtingerBarbara Kofler
Mar 19, 2014·Oncogenesis·A BalbousL Karayan-Tapon
Oct 30, 2014·Nucleic Acids Research·Damian SzklarczykChristian von Mering
Nov 8, 2014·Nucleic Acids Research·Nathan Wong, Xiaowei Wang
Feb 15, 2015·EMBO Reports·Raymond PagliariniWilliam R Sellers
Apr 10, 2015·Nature Reviews. Cancer·Frank B FurnariPaul S Mischel
Mar 25, 2018·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Benji LvKai Qu
Apr 19, 2018·Folia medica·George St Stoyanov, Deyan L Dzhenkov
Jul 29, 2018·Journal of the Neurological Sciences·Masahiko WanibuchiOsamu Honmou

❮ Previous
Next ❯

Citations

Apr 4, 2021·Cancers·Marta B LopesBruno M Costa

❮ Previous
Next ❯

Software Mentioned

DAVID
Panther
Cytoscape
GREAT
WGCNA
GEPIA
R

Related Concepts

Related Feeds

Cell Signaling by Tyrosine Kinases

Receptor tyrosine kinases (RTKs) are the high-affinity cell surface receptors for many polypeptide growth factors, cytokines, and hormones. RTKs have been shown not only to be key regulators of normal cellular processes but also to have a critical role in the development and progression of many types of cancer. Discover the latest research on cell signaling and RTK here.