Abstract
Chronic obstructive pulmonary disease (COPD) and lung adenocarcinoma (LUAD) are common disorders and usually co-exists. However, genetic mechanisms between COPD and LUAD are rarely reported. This study aims to identify susceptible genes of COPD with LUAD. Using the published data of GSE106899, co-expression modules were constructed by weighted gene co-expression network analysis (WGCNA). Subsequently, top 50 genes in the most tumor-related module were identified, among which hub genes were selected and validated. Twenty co-expression modules were constructed on 13,865 genes from 62 lung tissues of COPD patients with or without LUAD, in which one module (blue) was most related to tumorigenesis. Functional enrichment analyses showed that the genes in the blue module were mainly enriched in cell cycle, DNA transcription/replication and cancer pathways, etc. Combined with protein-protein interaction network, MTA1, PKMYT1 and FZR1 genes had the most intramodular connectivity, which were regarded as the hub genes. However, only FZR1 was validated to be overexpressed in lung tissues of COPD with LUAD and cigarette smoke extract-stimulated A549 cells, a human LUAD cell line. This study suggests overexpression of FZR1 may play a key rol...Continue Reading
References
Sep 26, 2000·Molecular and Cellular Biology·C S SorensenJ Lukas
Nov 5, 2003·Genome Research·Paul ShannonTrey Ideker
Apr 26, 2007·The American Journal of Pathology·Norman L LehmanPeter K Jackson
Jun 17, 2008·Nature Cell Biology·Irene García-HigueraMarcos Malumbres
Jun 21, 2008·American Journal of Respiratory and Critical Care Medicine·David O WilsonFrank C Sciurba
Dec 31, 2008·BMC Bioinformatics·Peter Langfelder, Steve Horvath
Jan 10, 2009·Nature Protocols·Da Wei HuangRichard A Lempicki
Feb 7, 2009·The European Respiratory Journal·R P YoungG D Gamble
Oct 20, 2009·The Journal of Biological Chemistry·Da-Qiang LiRakesh Kumar
Mar 29, 2011·Seminars in Cell & Developmental Biology·Manuel EgurenMarcos Malumbres
Dec 23, 2011·Bioorganic & Medicinal Chemistry Letters·Alexander RoheMatthias Schmidt
Mar 8, 2013·Nature Reviews. Cancer·A McGarry Houghton
Mar 29, 2014·Annals of the American Thoracic Society·Thomas Ferkol, Dean Schraufnagel
Oct 27, 2014·Cancer Metastasis Reviews·Nirmalya SenRakesh Kumar
Oct 29, 2014·The EMBO Journal·Lorenzo LafranchiMarcel A T M van Vugt
Jun 10, 2015·Drug Design, Development and Therapy·Shuya ZhaoJun Zhang
Jul 23, 2015·American Journal of Respiratory and Critical Care Medicine·Robert P YoungDenise Aberle
Sep 1, 2015·Laboratory Investigation; a Journal of Technical Methods and Pathology·Lingli GuoFu-Qiang Wen
Sep 14, 2015·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·A L Durham, I M Adcock
Sep 23, 2016·Oncotarget·Lisa J CrawfordAlexandra E Irvine
Dec 8, 2016·Nucleic Acids Research·Damian SzklarczykChristian von Mering
Feb 9, 2017·Cancer Discovery·Lixin WanWenyi Wei
Apr 14, 2017·BMC Systems Biology·Juan A BotíaMichael E Weale
Jun 27, 2017·Experimental Cell Research·Lei LiuFeng Zhang
Feb 17, 2018·Chest·Laurie L CarrRussell P Bowler
Apr 27, 2018·International Journal of Chronic Obstructive Pulmonary Disease·Wei WangWei Xiao
May 11, 2018·Toxicology Letters·Haiyan YangYadong Wang
Oct 1, 2018·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Yangyang LiuYongbing Chen
Nov 28, 2018·Molecular Psychiatry·Eugenia RadulescuDaniel R Weinberger
Jan 16, 2019·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Ester ZamarrónFrancisco García-Río
May 14, 2019·Expert Opinion on Therapeutic Targets·Gaetano CaramoriIan M Adcock
May 28, 2019·Respiratory Medicine·Gunnar R HusebøTomas Eagan
Jun 8, 2019·European Review for Medical and Pharmacological Sciences·Q-S SunH Sun