PMID: 641377May 1, 1978Paper

Identification of systemic phototoxic drugs by human intradermal assay

The Journal of Investigative Dermatology
K H Kaidbey, A M Kligman

Abstract

An improved method is presented for the detection of systemically administered photosensitizing drugs in humans. Test agents were injected intradermally in physiologic saline and then exposed to broad spectrum radiation from a Xenon solar simulator. Several clinically recognized photosensitizers were identified by this technique. The activating spectrum depended on the test drug. Sulfonamides and vinblastin were activated by sunburning erythemic radiation (UV-B), while tetracyclines, nalidixic acid and phenothiazines by near UV (UV-A), and chlorothiazide by both. It is suggested that intradermal phototesting offers a means of verifying the phototoxic potential of agents suspected clinically of provoking a photosensitivity eruption.

Citations

Mar 1, 1988·Clinical and Experimental Dermatology·A L Wright, G B Colver
Feb 1, 1997·Photodermatology, Photoimmunology & Photomedicine·E Selvaag, P Thune
Feb 1, 1997·Photodermatology, Photoimmunology & Photomedicine·C AugustinO Damour
Jun 15, 1999·Medical & Biological Engineering & Computing·O DamourA F Black
Aug 14, 2003·Photodermatology, Photoimmunology & Photomedicine·Takeshi Horio
Oct 1, 1982·The British Journal of Dermatology·J FergusonW Frain-Bell
Apr 1, 1980·Contact Dermatitis·K H Kaidbey, A M Kligman
Jun 1, 1987·The British Journal of Dermatology·H A AddoW Frain-Bell
Jul 1, 1982·Photochemistry and Photobiology·G F WebsterA M Kligman
Feb 18, 2012·Cutaneous and Ocular Toxicology·Dena ElkeebHoward Maibach
Jul 1, 1981·The Journal of Investigative Dermatology·K E Kochevar
Apr 1, 1985·The Journal of Investigative Dermatology·L H KligmanA M Kligman
May 1, 1992·The Journal of Investigative Dermatology·R M LasarowE C Gomez
Jul 3, 2007·Toxicology in Vitro : an International Journal Published in Association with BIBRA·Damien LelièvreJosé Cotovio

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