Identification of target genes of the lymphoid-specific transcription factor Oct2

Immunobiology
P PfistererThomas Wirth

Abstract

The Oct2 transcription factor is expressed predominantly in B lymphocytes and plays an essential role during the terminal phase of B cell differentiation. The regulatory regions of several genes specifically expressed in B cells contain functional binding sites for Oct2. Nevertheless, none of the genes originally thought to be regulated by Oct2 were affected in their expression in Oct2-deficient B cells. In an attempt to find such elusive Oct2 target genes and to understand the molecular function of Oct2 in B cell development, we isolated cDNAs for Oct2 target genes. So far, we have identified five potential targets for Oct2: the membrane glycoprotein CD36, the cysteine-rich secreted protein 3 (CRISP-3), a mouse homolog of the human monocyte/neutrophil elastase inhibitor (mEI) and two unknown cDNA sequences Nov1 and Nov2. These target genes show quite distinct expression patterns demonstrating that transcription factors in addition to Oct2 are involved in their regulation. Whereas CD36 and mEI were expressed in all hematopoetic cell lines containing Oct2,. CRISP-3 is pre-B cell-specific, Nov1 is plasma B cell-specific and Nov2 is B cell-specifically expressed.

References

Jul 1, 1992·Molecular and Cellular Biology·A AnnweilerT Wirth
Jan 11, 1991·Nucleic Acids Research·T WirthB Oeler
Jun 1, 1991·Genes & Development·M G Rosenfeld
Jan 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·H YagitaK Okumura
Aug 1, 1989·European Journal of Immunology·P AltevogtB Kyewski
Dec 8, 1988·Nature·R A Sturm, W Herr
Apr 1, 1984·Proceedings of the National Academy of Sciences of the United States of America·G M Church, W Gilbert
Jan 26, 1995·Nature·M GstaigerC M Hovens
Sep 27, 1994·Proceedings of the National Academy of Sciences of the United States of America·P A FurthL Hennighausen
Apr 29, 1993·Biochimica Et Biophysica Acta·C P Verrijzer, P C Van der Vliet
Dec 15, 1995·The Journal of Biological Chemistry·P PfistererT Wirth
Dec 1, 1996·European Journal of Immunology·P J NielsenW Schaffner

❮ Previous
Next ❯

Citations

Feb 6, 2004·Proceedings of the National Academy of Sciences of the United States of America·Victoria E H WangPhillip A Sharp
Apr 2, 2014·Frontiers in Immunology·Lynn CorcoranStephane Chevrier
Dec 20, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·U KimR G Roeder
Aug 1, 2000·American Journal of Physiology. Gastrointestinal and Liver Physiology·L A DensonH C Jacobs
Feb 24, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·Lynn M CorcoranPatrick O Humbert

❮ Previous
Next ❯

Related Concepts

Related Feeds

B cell Differentiation

Depending on the signal received through the B cell receptor and other receptors, B cells differentiate into follicular or marginal zone B cells. Here is the latest research pertaining to this differentiation process.