Identification of teratogenic polymethoxy-1-alkenes fromCylindrospermopsis raciborskii , and taxonomically diverse freshwater cyanobacteria and green algae

Harmful Algae
Asha Jaja-ChimedzaJohn P Berry

Abstract

Cylindrospermopsis raciborskii is among the most commonly recognized toxigenic cyanobacteria associated with harmful algal blooms (HAB) in freshwater systems, and specifically associated with multiple water-soluble toxins. Lipophilic metabolites fromC. raciborskii, however, were previously shown to exert teratogenicity (i.e. inhibition of vertebrate development) in the zebrafish (Daniorerio) embryo model, specifically suggesting the presence of additional bioactive compounds unrelated to the currently known toxins. In the present study, a series of known teratogenic polymethoxy-1-alkenes (PMA) were identified, purified and chemically characterized from an otherwise well-characterized strain of toxigenicC. raciborskii. Although PMA have been previously identified in other cyanobacteria, this is the first time they have been identified from this recognized HAB species. Following their identification fromC. raciborskii, the taxonomic distribution of the PMA was additionally investigated by chemical screening of a freshwater algal (i.e. cyanobacteria, green algal) culture collection. Screening suggests that these compounds are distributed among phylogenetically diverse taxa. Furthermore, parallel screening of the algal culture coll...Continue Reading

References

Sep 15, 1999·Toxicon : Official Journal of the International Society on Toxinology·M L Saker, G K Eaglesham
Mar 24, 2004·Aquatic Toxicology·Kathi A LefebvreNathaniel L Scholz
Oct 6, 2006·Comparative Biochemistry and Physiology. Toxicology & Pharmacology : CBP·John P BerryMichael C Schmale
Feb 13, 2008·FEMS Microbiology Ecology·Miroslav GantarKathleen S Rein
May 8, 2013·Toxicon : Official Journal of the International Society on Toxinology·András AcsAnna Farkas
Aug 12, 2014·Aquatic Toxicology·Adam JonasKlara Hilscherova

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Citations

Oct 7, 2019·Toxicon : Official Journal of the International Society on Toxinology·Piotr RzymskiMikołaj Kokociński

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