Identification of the CCR5-Delta32 HIV resistance allele and new mutations of the CCR5 gene in different Tunisian populations

Human Immunology
Asma JliziWassila Carpentier

Abstract

Polymorphisms in some chemokine receptor genes are associated with susceptibility to and progression of human immunodeficiency virus-1 (HIV-1) infection. Most mutations detected in the CC-chemokine receptor 5 (CCR5) gene are specific to different populations. In this study, we focused on polymorphisms of the CCR5 coding region in three healthy populations from Tunisia, corresponding to a cosmopolitan population from Tunis, and two isolated Berber populations. In addition to the CCR5-Delta32 deletion, eleven single nucleotide polymorphisms were detected. Some of these point mutations were associated with the same genotype and even the same haplotype. The (L55Q-C101X), I124, V131F, T143N, A159V, I237, T239A and G301R alleles have not been described previously, whereas the CCR5-Delta32, L55Q, A335V and Y339F variants have already been reported in the literature. The distribution and frequency of these variants were different among the three groups studied, a result in agreement with the mosaic genetic structure of the Tunisian population. To determine whether these alleles affect HIV-1 transmission, we compared allele frequencies between healthy and HIV-1 infected individuals from Tunis. The frequency of the CCR5-Delta32 variant w...Continue Reading

References

May 1, 1994·Trends in Pharmacological Sciences·R Horuk
May 1, 1997·Nature Genetics·J J MartinsonJ B Clegg
Dec 18, 1997·American Journal of Human Genetics·M CarringtonM Dean
Aug 5, 2000·Microbes and Infection·M MagierowskaF Barré-Sinoussi
Mar 8, 2002·European Journal of Immunogenetics : Official Journal of the British Society for Histocompatibility and Immunogenetics·B Y LoveslatiA B Elgaaied
Mar 6, 2004·Genetic Testing·G Lucotte, P Smets
Jun 8, 2004·Annals of Human Genetics·K Fadhlaoui-ZidA Bennamar El gaaied
Dec 4, 2004·AIDS·Corinne Capoulade-MétayIoannis Theodorou
Apr 27, 2005·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Liying MaCorinne Capoulade-Métay
Jun 7, 2005·Trends in Microbiology·Roland R Regoes, Sebastian Bonhoeffer
Jul 12, 2005·Forensic Science International : Synergy·Sabeh FrigiAmel El Gaaied
Oct 12, 2005·PLoS Biology·John NovembreMontgomery Slatkin

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Citations

Jun 21, 2011·Diagnostic Pathology·Hejer ElmahmoudiEmna Gouider
Aug 21, 2013·International Journal of Immunogenetics·S H Al-MahruqiA A Al-Jabri
Jul 23, 2013·Journal of Biomolecular Structure & Dynamics·Nejla StambouliAmel Ben Ammar Elgaied
May 6, 2010·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Asongna T FolefocColleen A Flanagan
Jan 18, 2013·Journal of Clinical Laboratory Analysis·Palanee AmmaranondSirimarn Mardkhumchan
Aug 12, 2009·Molecular Biology Reports·Lidan XuSongbin Fu

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