PMID: 9421145Jan 8, 1998Paper

Identification of the cellular source of laminin beta2 in adult and developing vertebrate retinae

The Journal of Comparative Neurology
R T LibbyD D Hunter

Abstract

The interphotoreceptor matrix (IPM) is a specialized extracellular matrix that surrounds the inner and outer segments of photoreceptors. This matrix contains molecules that may be important in directing photoreceptor differentiation and survival. For example, one molecule that we have previously identified as a component of the IPM, laminin beta2 (formerly known as s-laminin), is implicated in the differentiation of rod photoreceptor cells. Developmentally, laminin beta2 is present before rod birth in a position that is consistent with a role in directing rod differentiation; it is found, in both the rat and skate, in the ventricular space that ultimately becomes the IPM. In this study, we identify the source of laminin beta2 in the adult and developing retina. Both immunohistochemistry in the adult skate retina and in situ hybridizations in the adult rat retina reveal that laminin beta2 is produced by Müller cells. In addition, in the skate but not the rat retina, retinal pigment epithelial cells may be an alternative source of laminin beta2. During development, however, laminin beta2 is present before the birth of Müller glial cells; at this stage of development, laminin beta2 RNA is present within the neuroepithelial layer i...Continue Reading

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Citations

Aug 23, 2007·Visual Neuroscience·Viktória DénesWilliam J Brunken
Nov 17, 2012·Cell Adhesion & Migration·Malia M Edwards, Olivier Lefebvre
Nov 23, 2013·Journal of Neuroscience Research·Camila Hochman-MendezTatiana Coelho-Sampaio
Oct 13, 2017·The Journal of Comparative Neurology·Dale D HunterWilliam J Brunken
May 10, 2005·The Journal of Comparative Neurology·Thomas ClaudepierreWilliam J Brunken
Nov 3, 2010·The European Journal of Neuroscience·David M SherryMuayyad R Al-Ubaidi
Nov 24, 2004·Molecular and Cellular Neurosciences·Dale D HunterWilliam J Brunken
Dec 27, 2006·Molecular and Cellular Neurosciences·Christophe EglesDale D Hunter
Feb 27, 2007·Experimental Eye Research·Erin Tolhurst DunkleDennis O Clegg

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