PMID: 9188080May 12, 1997Paper

Identification of the cholinergic neurons in guinea-pig sphincter of Oddi ganglia

Journal of the Autonomic Nervous System
E K TalmageG M Mawe

Abstract

The muscular tone of the sphincter of Oddi (SO) can be up- or down-regulated by neurons that lie within ganglia in the wall of the tissue. Previous studies have demonstrated that neurons in the ganglia of the guinea-pig SO can be classified into two major populations, one of which expresses tachykinins and enkephalin and another which expresses nitric oxide synthase. Although results of previous pharmacological studies indicate that acetylcholine is released in the SO, the neurons that express this neurotransmitter have not previously been identified. This study was conducted to establish which neurons in the ganglia of the guinea-pig SO are cholinergic by examining the distribution of choline acetyltransferase (ChAT) immunoreactivity, since the enzyme, ChAT is necessary for acetylcholine synthesis. Choline acetyltransferase immunoreactivity was intense and widespread in the ganglionated plexus of the SO. ChAT-immunoreactive nerve fibers were present in ganglia, interganglionic fiber bundles and in the circular muscle layer. Neurons that were immunoreactive for ChAT comprised about 69% of the population and most of these neurons were also tachykinin-immunoreactive. Co-expression of ChAT and nitric oxide synthase was not observe...Continue Reading

References

Mar 1, 1992·The Journal of Comparative Neurology·E K TalmageG M Mawe
Sep 1, 1990·Journal of the Autonomic Nervous System·C DahlstrandH Ahlman
Feb 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·J E KrauseA D Hershey
Jan 1, 1988·Regulatory Peptides·C DahlstrandH Ahlman
Dec 30, 1989·Journal of the Autonomic Nervous System·F VongalisG S Taylor
Jun 1, 1988·The Journal of Clinical Investigation·J W WileyC Owyang
Nov 14, 1983·Brain Research·R J ThompsonJ Rode
Jan 30, 1995·The Journal of Comparative Neurology·D G WellsG M Mawe
Mar 6, 1995·The Journal of Comparative Neurology·M SchemannM Mäder
Mar 2, 1993·European Journal of Pharmacology·J G PauletzkiE A Shaffer
Jul 1, 1993·Canadian Journal of Physiology and Pharmacology·H D AllescherM Classen
May 1, 1996·Cell and Tissue Research·E K TalmageG M Mawe
Aug 1, 1996·Cell and Tissue Research·G M MaweR L Parsons
Jul 11, 1998·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·K Hillsley, G M Mawe

❮ Previous
Next ❯

Citations

Mar 16, 2007·Digestive Diseases and Sciences·Antonio Bosch, Luis R Peña
Sep 12, 2000·Current Gastroenterology Reports·A L KennedyG M Mawe
Jul 11, 1998·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·K Hillsley, G M Mawe
Aug 7, 2009·Pancreatology : Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]·Cuiping LiXiaohua Hou
Mar 12, 2008·HPB : the Official Journal of the International Hepato Pancreato Biliary Association·Y SonodaG T P Saccone
Sep 24, 2004·The Anatomical Record. Part A, Discoveries in Molecular, Cellular, and Evolutionary Biology·Onesmo B BalembaGary M Mawe
Jan 1, 2013·Polish Journal of Veterinary Sciences·O Tomaszewska, J Kaleczyc
Jul 17, 1999·The American Journal of Physiology·G M Mawe, A L Kennedy
Jul 12, 2001·American Journal of Physiology. Gastrointestinal and Liver Physiology·B P Manning, G M Mawe
Nov 14, 1998·The American Journal of Physiology·K Hillsley, G M Mawe

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.