PMID: 9432005Feb 7, 1998Paper

Identification of the common antigenic determinant shared by Streptococcus pneumoniae serotypes 35A and 20 capsular polysaccharides--structural analysis of the Streptococcus pneumoniae serotype 35A capsular polysaccharide

European Journal of Biochemistry
L M BeynonM B Perry

Abstract

The specific polysaccharide antigen of Streptococcus pneumoniae serotype 35A was shown, by a combination of one- and two-dimensional NMR methods and chemical analyses, to be a high-molecular-mass polymer composed of D-galactose, D-glucose, mannitol, and phosphate (3:1:1:1). The pentasaccharide repeating unit is polymerized through phosphate diester linkages to give the structure, [formula in text] O-Acetyl substituents are present at positions 5 and 6 of the 3)-beta-D-Galf residue and at position 2 of the 6)-beta-D-Galf residue. The capsular polysaccharides of S. pneumoniae serotypes 20 and 35A both contain the disaccharide unit -->3)-beta-D-Galf-(1-->3)-beta-D-Glcp-(1--> which is the probable structural determinant responsible for the serological cross reactivity of the two polysaccharides.

References

Apr 1, 1983·Canadian Journal of Biochemistry and Cell Biology = Revue Canadienne De Biochimie Et Biologie Cellulaire·J C RichardsD J Carlo
Nov 28, 1994·Archives of Internal Medicine·D S FedsonC V Broome

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Citations

Jun 9, 2004·Journal of Clinical Microbiology·Markus HufnagelJohannes Huebner
Mar 24, 2006·Immunology Letters·M Y K LeungK P Fung
Jul 1, 2017·Journal of Clinical Microbiology·K Aaron GenoJinghua Yang
Mar 10, 2017·Science Translational Medicine·Benjamin SchumannPeter H Seeberger
Aug 23, 2017·Scientific Reports·Alexey G GerbstNikolay E Nifantiev

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