PMID: 8951999Nov 14, 1996Paper

Identification of the dipteran Leu-callatostatin peptide family: characterisation of the prohormone gene from Calliphora vomitoria and Lucilia cuprina

Regulatory Peptides
P D EastA Thorpe

Abstract

The prohormone gene encoding the Leu-callatostatin peptides has been isolated from a Calliphora vomitoria genomic DNA library and its homologue was cloned from genomic and cDNA libraries of another blowfly species, Lucilia cuprina. Gene and prohormone structure and organisation are essentially identical in the two species. The Leu-callatostatin gene consists of at least 3 exons. The prohormone is encoded on exons two and three and the two blocks of putative Leu-callatostatin peptides are carried on separate exons. It is 180 amino-acids long, begins with a short signal peptide and contains two blocks of tandemly arranged Leu-callatostatin peptides separated by an acidic spacer region. The prohormone contains 5 copies of the C-terminal sequence -YX FGL characteristic of the Leu-callatostatin family. Complete endoproteolytic processing at all possible pairs of basic amino acids would generate 5 different Leu-callatostatin octapeptides. Two larger Leu-callatostatins could be released if processing was not complete at two of the sites. None of the 3 peptides encoded in the first block was identified in previous purification studies of the callatostatin peptides. The second block, located at the carboxyl end of the prohormone, contai...Continue Reading

References

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Citations

Jan 14, 1999·The Journal of Comparative Neurology·T R Bhatt, F M Horodyski
Jul 13, 2000·Biochemical and Biophysical Research Communications·C LenzC J Grimmelikhuijzen
Nov 6, 2003·Insect Biochemistry and Molecular Biology·P MoshitzkyS W Applebaum
Jan 1, 1997·Peptides·H DuveA Thorpe
Nov 6, 2001·Molecular and Cellular Endocrinology·M Meyering-VosF Sehnal
Oct 8, 2003·Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology·M Meyering-Vos, K H Hoffmann
Feb 17, 2000·Annals of the New York Academy of Sciences·W G BendenaS S Tobe
Sep 14, 2006·Annual Review of Entomology·Barbara Stay, Stephen S Tobe
Apr 11, 2014·PloS One·Man-Yeon ChoiReinhard Predel
Oct 30, 2015·Archives of Insect Biochemistry and Physiology·Franziska WendeKlaus H Hoffmann
Oct 19, 2010·Peptides·Francisco Martínez-PérezStephen S Tobe
Dec 10, 2008·Insect Biochemistry and Molecular Biology·Jan A Veenstra
Jun 24, 2004·Archives of Insect Biochemistry and Physiology·Mohatmed Abdel-LatiefKlaus H Hoffmann
Sep 11, 2003·Microscopy Research and Technique·Sakiko Siga
Jan 25, 2000·Archives of Insect Biochemistry and Physiology·J A Veenstra

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