Identification of the envelope V3 loop as a determinant of a CD4-negative neuronal cell tropism for HIV-1

Virology
J R TrujilloM Essex

Abstract

Some neuronal-derived CD4-negative cells are susceptible to infection with human immunodeficiency virus type 1 (HIV-1). Galactosyl ceramide is an alternate receptor for HIV-1 that appears to bind in vitro to the C2, V3, V4, and V5 regions of gp120. Amino acid variation in the V3 loop of HIV-1 affects cellular tropism in CD4-positive cells, but its effect on CD4-negative cells has not been fully analyzed. Here, we describe the effect of amino acid changes in V3 on the HIV-1 infection of a CD4-negative neuronal cell line, SK-N-MC. The sequence of the V3 domain was found to dramatically alter virus infectivity. Furthermore, a gp120 V3 loop neutralizing monoclonal antibody blocked HIV-1 infection of SK-N-MC cells. This data suggests that V3 may also serve as a primary viral determinant for infectivity of CD4-negative cells.

Citations

Dec 16, 2005·Cell Research·J Roberto TrujilloRobert C Gallo
Mar 16, 2007·Proceedings of the National Academy of Sciences of the United States of America·J Roberto TrujilloJoseph D Brain
May 20, 1998·Proceedings of the National Academy of Sciences of the United States of America·W K WangT H Lee
Nov 7, 2000·Journal of Acquired Immune Deficiency Syndromes : JAIDS·J R TrujilloJ D Brain
Nov 1, 1996·Journal of Biomedical Science·D.L. Kolson, R.J. Pomerantz
Feb 18, 2016·Scientific Reports·Hui-Shuang ShenXian-Ming Pan
Feb 1, 2003·FEBS Letters·Alexander M ColeOtto O Yang
Apr 3, 2007·Virus Research·Sirawat Srichatrapimuk, Prasert Auewarakul
Jul 11, 1998·Virology·J FantiniN Yahi
Jan 13, 2006·Virology·Thumbi Ndung'uMax Essex
Jun 29, 2005·The Journal of Biological Chemistry·Keisuke YusaShinji Harada

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