Identification of the envelope V3 loop as the primary determinant of cell tropism in HIV-1

Science
S S HwangB R Cullen

Abstract

Cells of the monocyte-macrophage lineage are targets for human immunodeficiency virus-1 (HIV-1) infection in vivo. However, many laboratory strains of HIV-1 that efficiently infect transformed T cell lines replicate poorly in macrophages. A 20-amino acid sequence from the macrophage-tropic BaL isolate of HIV-1 was sufficient to confer macrophage tropism on HTLV-IIIB, a T cell line--tropic isolate. This small sequence element is in the V3 loop, the envelope domain that is the principal neutralizing determinant of HIV-1. Thus, the V3 loop not only serves as a target of the host immune response but is also pivotal in determining HIV-1 tissue tropism.

References

Dec 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·T F WolfsJ Goudsmit
Nov 1, 1990·Journal of Virology·S KimD Baltimore
Apr 1, 1990·The Journal of General Virology·M O McClureR A Weiss
Apr 1, 1990·Virology·B J PottsM A Martin
May 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·G C BaldwinD W Golde
Jan 1, 1990·Annual Review of Immunology·M S MeltzerH E Gendelman
Sep 1, 1990·Journal of Virology·R CollmanF Gonzalez-Scarano
Mar 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·T J PalkerB F Haynes
May 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·J R RuscheP J Fischinger
Jun 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·J GoudsmitD C Gajdusek
Jul 1, 1989·The Journal of General Virology·K B Andersen, H Skov
Jan 7, 1988·Nature·R A FisherR T Schooley
Jul 11, 1986·Science·S GartnerM Popovic
Sep 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·C A WileyM B Oldstone
Jan 1, 1987·Methods in Enzymology·K B Mullis, F A Faloona
Aug 1, 1987·The Journal of General Virology·K B Andersen

❮ Previous
Next ❯

Citations

Jun 10, 1998·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·S BrambillaE M Silini
Nov 1, 1995·Journal of Medical Virology·J N NkengasongP Nys
Nov 1, 1992·International Journal of Cell Cloning·Q J Sattentau
Jul 1, 1996·Journal of Biomedical Science·N. Ahmad
Aug 5, 2011·Archives of Virology·Salvatore DimonteMuhammed Babakir-Mina
May 25, 2006·Journal of Molecular Modeling·Kelby B NapierJohn O Trent
Jul 22, 2006·Science in China. Series C, Life Sciences·Zhengfu Wang, Zhizhong Cui
Jan 13, 2012·Current HIV/AIDS Reports·Kathryn Twigg ArrildtRonald Swanstrom
Jun 1, 1992·Immunology Today·L E Eiden, J D Lifson
Aug 5, 1996·Transfusion Science·S Joshi, R L Joshi
Dec 1, 1993·Trends in Microbiology·N SignoretQ J Sattentau
Jul 25, 2012·Computers in Biology and Medicine·Watshara ShoombuatongTanawan Samleerat
May 26, 2005·Immunology Letters·Xiao-Nan DongYing-Hua Chen
Mar 5, 1999·Immunology Letters·J A McKeating, P Balfe
Jul 1, 1997·Journal of Virological Methods·C GuillonR A Gruters
Sep 1, 2001·Antiviral Research·M R RuffF A Ruscetti
Jun 19, 2001·Virus Research·K M McGrathR Swanstrom
Mar 19, 2003·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Harold OforiPaweł P Jagodzinski
Sep 1, 1996·Current Biology : CB·D Wilkinson
Jul 31, 1998·Micron : the International Research and Review Journal for Microscopy·T GotoK Ikuta
May 2, 2000·Drug Discovery Today·W S BlairO B Wallace
Oct 6, 2001·Current Opinion in Microbiology·M D Miller, D J Hazuda
Oct 19, 2013·International Journal of Oral Science·Fariba S Younai

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.