PMID: 10894752Jul 14, 2000

Identification of the Escherichia coli nicotinic acid mononucleotide adenylyltransferase gene

Journal of Bacteriology
R A MehlT P Begley


The gene (ybeN) coding for nicotinate mononucleotide adenylyltransferase, an NAD(P) biosynthetic enzyme, has been identified and overexpressed in Escherichia coli. This enzyme catalyzes the reversible adenylation of nicotinate mononucleotide and shows product inhibition. The rate of adenylation of nicotinate mononucleotide is at least 20 times faster than the rate of adenylation of nicotinamide mononucleotide.


Feb 25, 2003·Protein Expression and Purification·Monica EmanuelliGiulio Magni
Apr 26, 2003·Current Opinion in Chemical Biology·Andrei L Osterman, Ross Overbeek
Jul 27, 2002·Journal of Bacteriology·Svetlana Y GerdesAndrei L Osterman
Nov 26, 2002·Journal of Bacteriology·Oleg V KurnasovAndrei L Osterman
Oct 27, 2016·Molecular Microbiology·Timothy J BrickmanSandra K Armstrong
Nov 6, 2013·Proceedings of the National Academy of Sciences of the United States of America·Jee-Hyun KimDirk Schnappinger
Jun 27, 2017·Molecular Cell·Nadezda SedlyarovaEvgeny Nudler
Oct 31, 2017·Applied Biochemistry and Biotechnology·Xueying WangZongbao K Zhao


Jul 1, 1983·Journal of Bacteriology·K T HughesB M Olivera
Dec 24, 1997·Journal of Bacteriology·Nadia RaffaelliGiulio Magni
Sep 10, 1999·The Journal of Biological Chemistry·A GeerlofW V Shaw
Feb 12, 2008·Current Protocols in Molecular Biology·S Tabor

Related Concepts

Alkalescens-Dispar Group
Nicotinamide Mononucleotide
nicotinic acid ribonucleotide
Metabolic Inhibition
nicotinate mononucleotide
Nicotinate-nucleotide adenylyltransferase
Nicotinamide-Nucleotide Adenylyltransferase
Escherichia coli

Trending Feeds


Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Synapse Loss as Therapeutic Target in MS

As we age, the number of synapses present in the human brain starts to decline, but in neurodegenerative diseases this occurs at an accelerated rate. In MS, it has been shown that there is a reduction in synaptic density, which presents a potential target for treatment. Here is the latest research on synapse loss as a therapeutic target in MS.

Artificial Intelligence in Cardiac Imaging

Artificial intelligence (ai) techniques are increasingly applied to cardiovascular (cv) medicine in cardiac imaging analysis. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

Social Learning

Social learning involves learning new behaviors through observation, imitation and modeling. Follow this feed to stay up to date on the latest research.

Cell Atlas of the Human Eye

Constructing a cell atlas of the human eye will require transcriptomic and histologic analysis over the lifespan. This understanding will aid in the study of development and disease. Find the latest research pertaining to the Cell Atlas of the Human Eye here.

Single Cell Chromatin Profiling

Techniques like ATAC-seq and CUT&Tag have the potential to allow single cell profiling of chromatin accessibility, histones, and TFs. This will provide novel insight into cellular heterogeneity and cell states. Discover the latest research on single cell chromatin profiling here.

Genetic Screens in iPSC-derived Brain Cells

Genetic screening is a critical tool that can be employed to define and understand gene function and interaction. This feed focuses on genetic screens conducted using induced pluripotent stem cell (iPSC)-derived brain cells.