Identification of the het-r vegetative incompatibility gene of Podospora anserina as a member of the fast evolving HNWD gene family.

Current Genetics
Damien ChevanneMathieu Paoletti

Abstract

In fungi, vegetative incompatibility is a conspecific non-self recognition mechanism that restricts formation of viable heterokaryons when incompatible alleles of specific het loci interact. In Podospora anserina, three non-allelic incompatibility systems have been genetically defined involving interactions between het-c and het-d, het-c and het-e, het-r and het-v. het-d and het-e are paralogues belonging to the HNWD gene family that encode proteins of the STAND class. HET-D and HET-E proteins comprise an N-terminal HET effector domain, a central GTP binding site and a C-terminal WD repeat domain constituted of tandem repeats of highly conserved WD40 repeat units that define the specificity of alleles during incompatibility. The WD40 repeat units of the members of this HNWD family are undergoing concerted evolution. By combining genetic analysis and gain of function experiments, we demonstrate that an additional member of this family, HNWD2, corresponds to the het-r non-allelic incompatibility gene. As for het-d and het-e, allele specificity at the het-r locus is determined by the WD repeat domain. Natural isolates show allelic variation for het-r.

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Citations

May 13, 2010·BMC Evolutionary Biology·Damien ChevanneMathieu Paoletti
Dec 3, 2010·PloS One·Charles HallN Louise Glass
Jan 23, 2014·Molecular Biology and Evolution·Eric BastiaansMathieu Paoletti
Nov 16, 2014·Genome Biology and Evolution·Witold DyrkaSven J Saupe
Oct 2, 2009·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Mathieu Paoletti, Sven J Saupe
Nov 19, 2011·Fungal Genetics and Biology : FG & B·Denis L Lafontaine, Myron L Smith
Jan 2, 2014·Fungal Genetics and Biology : FG & B·M A Van der NestJ Stenlid
Feb 20, 2019·Bioscience, Biotechnology, and Biochemistry·Noriko MoriJun-Ichi Maruyama
Apr 17, 2013·G3 : Genes - Genomes - Genetics·Frédérique BidardSven J Saupe
Apr 14, 2017·Biomolecules·Antoine Loquet, Sven J Saupe
Jul 25, 2020·Proceedings of the National Academy of Sciences of the United States of America·Asen DaskalovN Louise Glass
Jun 14, 2019·BMC Genomics·Christian P KubicekIrina S Druzhinina
Mar 4, 2017·Microbiology Spectrum·Asen DaskalovN Louise Glass
Oct 16, 2020·Journal of Molecular Biology·Witold DyrkaSven J Saupe

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